Application of a Novel ‘Make and Test in Parallel’ Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects

PURPOSE: GDC-0810, administered orally, was used in Phase I and II clinical studies to treat estrogen receptor positive breast cancers. It contains N-methyl-D-glucamine (NMG) salt of GDC-0810 with 10% sodium lauryl sulfate (SLS) as a surfactant and 15% sodium bicarbonate (NaHCO(3)) as an alkalizing...

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Detalles Bibliográficos
Autores principales: Cheeti, Sravanthi, Hou, Hao Helen, Nelson, Eric, Walker, Helen, Chen, Buyun, Morley, Roland, Gates, Mary, Musib, Luna, Girish, Sandhya, Sahasranaman, Srikumar, Liu, Lichuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208608/
https://www.ncbi.nlm.nih.gov/pubmed/30324422
http://dx.doi.org/10.1007/s11095-018-2516-0

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