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Distinct [(18)F]THK5351 binding patterns in primary progressive aphasia variants

PURPOSE: To assess the binding of the PET tracer [(18)F]THK5351 in patients with different primary progressive aphasia (PPA) variants and its correlation with clinical deficits. The majority of patients with nonfluent variant (NFV) and logopenic variant (LV) PPA have underlying tauopathy of the fron...

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Autores principales: Schaeverbeke, Jolien, Evenepoel, Charlotte, Declercq, Lieven, Gabel, Silvy, Meersmans, Karen, Bruffaerts, Rose, Adamczuk, Kate, Dries, Eva, Van Bouwel, Karen, Sieben, Anne, Pijnenburg, Yolande, Peeters, Ronald, Bormans, Guy, Van Laere, Koen, Koole, Michel, Dupont, Patrick, Vandenberghe, Rik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208807/
https://www.ncbi.nlm.nih.gov/pubmed/29946950
http://dx.doi.org/10.1007/s00259-018-4075-3
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author Schaeverbeke, Jolien
Evenepoel, Charlotte
Declercq, Lieven
Gabel, Silvy
Meersmans, Karen
Bruffaerts, Rose
Adamczuk, Kate
Dries, Eva
Van Bouwel, Karen
Sieben, Anne
Pijnenburg, Yolande
Peeters, Ronald
Bormans, Guy
Van Laere, Koen
Koole, Michel
Dupont, Patrick
Vandenberghe, Rik
author_facet Schaeverbeke, Jolien
Evenepoel, Charlotte
Declercq, Lieven
Gabel, Silvy
Meersmans, Karen
Bruffaerts, Rose
Adamczuk, Kate
Dries, Eva
Van Bouwel, Karen
Sieben, Anne
Pijnenburg, Yolande
Peeters, Ronald
Bormans, Guy
Van Laere, Koen
Koole, Michel
Dupont, Patrick
Vandenberghe, Rik
author_sort Schaeverbeke, Jolien
collection PubMed
description PURPOSE: To assess the binding of the PET tracer [(18)F]THK5351 in patients with different primary progressive aphasia (PPA) variants and its correlation with clinical deficits. The majority of patients with nonfluent variant (NFV) and logopenic variant (LV) PPA have underlying tauopathy of the frontotemporal lobar or Alzheimer disease type, respectively, while patients with the semantic variant (SV) have predominantly transactive response DNA binding protein 43-kDa pathology. METHODS: The study included 20 PPA patients consecutively recruited through a memory clinic (12 NFV, 5 SV, 3 LV), and 20 healthy controls. All participants received an extensive neurolinguistic assessment, magnetic resonance imaging and amyloid biomarker tests. [(18)F]THK5351 binding patterns were assessed on standardized uptake value ratio (SUVR) images with the cerebellar grey matter as the reference using statistical parametric mapping. Whole-brain voxel-wise regression analysis was performed to evaluate the association between [(18)F]THK5351 SUVR images and neurolinguistic scores. Analyses were performed with and without partial volume correction. RESULTS: Patients with NFV showed increased binding in the supplementary motor area, left premotor cortex, thalamus, basal ganglia and midbrain compared with controls and patients with SV. Patients with SV had increased binding in the temporal lobes bilaterally and in the right ventromedial frontal cortex compared with controls and patients with NFV. The whole-brain voxel-wise regression analysis revealed a correlation between agrammatism and motor speech impairment, and [(18)F]THK5351 binding in the left supplementary motor area and left postcentral gyrus. Analysis of [(18)F]THK5351 scans without partial volume correction revealed similar results. CONCLUSION: [(18)F]THK5351 imaging shows a topography closely matching the anatomical distribution of predicted underlying pathology characteristic of NFV and SV PPA. [(18)F]THK5351 binding correlates with the severity of clinical impairment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00259-018-4075-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-62088072018-11-09 Distinct [(18)F]THK5351 binding patterns in primary progressive aphasia variants Schaeverbeke, Jolien Evenepoel, Charlotte Declercq, Lieven Gabel, Silvy Meersmans, Karen Bruffaerts, Rose Adamczuk, Kate Dries, Eva Van Bouwel, Karen Sieben, Anne Pijnenburg, Yolande Peeters, Ronald Bormans, Guy Van Laere, Koen Koole, Michel Dupont, Patrick Vandenberghe, Rik Eur J Nucl Med Mol Imaging Original Article PURPOSE: To assess the binding of the PET tracer [(18)F]THK5351 in patients with different primary progressive aphasia (PPA) variants and its correlation with clinical deficits. The majority of patients with nonfluent variant (NFV) and logopenic variant (LV) PPA have underlying tauopathy of the frontotemporal lobar or Alzheimer disease type, respectively, while patients with the semantic variant (SV) have predominantly transactive response DNA binding protein 43-kDa pathology. METHODS: The study included 20 PPA patients consecutively recruited through a memory clinic (12 NFV, 5 SV, 3 LV), and 20 healthy controls. All participants received an extensive neurolinguistic assessment, magnetic resonance imaging and amyloid biomarker tests. [(18)F]THK5351 binding patterns were assessed on standardized uptake value ratio (SUVR) images with the cerebellar grey matter as the reference using statistical parametric mapping. Whole-brain voxel-wise regression analysis was performed to evaluate the association between [(18)F]THK5351 SUVR images and neurolinguistic scores. Analyses were performed with and without partial volume correction. RESULTS: Patients with NFV showed increased binding in the supplementary motor area, left premotor cortex, thalamus, basal ganglia and midbrain compared with controls and patients with SV. Patients with SV had increased binding in the temporal lobes bilaterally and in the right ventromedial frontal cortex compared with controls and patients with NFV. The whole-brain voxel-wise regression analysis revealed a correlation between agrammatism and motor speech impairment, and [(18)F]THK5351 binding in the left supplementary motor area and left postcentral gyrus. Analysis of [(18)F]THK5351 scans without partial volume correction revealed similar results. CONCLUSION: [(18)F]THK5351 imaging shows a topography closely matching the anatomical distribution of predicted underlying pathology characteristic of NFV and SV PPA. [(18)F]THK5351 binding correlates with the severity of clinical impairment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00259-018-4075-3) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2018-06-26 2018 /pmc/articles/PMC6208807/ /pubmed/29946950 http://dx.doi.org/10.1007/s00259-018-4075-3 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Schaeverbeke, Jolien
Evenepoel, Charlotte
Declercq, Lieven
Gabel, Silvy
Meersmans, Karen
Bruffaerts, Rose
Adamczuk, Kate
Dries, Eva
Van Bouwel, Karen
Sieben, Anne
Pijnenburg, Yolande
Peeters, Ronald
Bormans, Guy
Van Laere, Koen
Koole, Michel
Dupont, Patrick
Vandenberghe, Rik
Distinct [(18)F]THK5351 binding patterns in primary progressive aphasia variants
title Distinct [(18)F]THK5351 binding patterns in primary progressive aphasia variants
title_full Distinct [(18)F]THK5351 binding patterns in primary progressive aphasia variants
title_fullStr Distinct [(18)F]THK5351 binding patterns in primary progressive aphasia variants
title_full_unstemmed Distinct [(18)F]THK5351 binding patterns in primary progressive aphasia variants
title_short Distinct [(18)F]THK5351 binding patterns in primary progressive aphasia variants
title_sort distinct [(18)f]thk5351 binding patterns in primary progressive aphasia variants
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208807/
https://www.ncbi.nlm.nih.gov/pubmed/29946950
http://dx.doi.org/10.1007/s00259-018-4075-3
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