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PISCOM: a new procedure for epilepsy combining ictal SPECT and interictal PET
PURPOSE: We present a modified version of the SISCOM procedure that uses interictal PET instead of interictal SPECT for seizure onset zone localization. We called this new nuclear imaging processing technique PISCOM (PET interictal subtracted ictal SPECT coregistered with MRI). METHODS: We retrospec...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208811/ https://www.ncbi.nlm.nih.gov/pubmed/30069576 http://dx.doi.org/10.1007/s00259-018-4080-6 |
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author | Perissinotti, Andrés Niñerola-Baizán, Aida Rubí, Sebastià Carreño, Mar Marti-Fuster, Berta Aparicio, Javier Mayoral, Maria Donaire, Antonio Sanchez-Izquierdo, Nuria Bargalló, Nuria Rumiá, Jordi Boget, Teresa Pons, Francesca Lomeña, Francisco Ros, Domènec Pavía, Javier Setoain, Xavier |
author_facet | Perissinotti, Andrés Niñerola-Baizán, Aida Rubí, Sebastià Carreño, Mar Marti-Fuster, Berta Aparicio, Javier Mayoral, Maria Donaire, Antonio Sanchez-Izquierdo, Nuria Bargalló, Nuria Rumiá, Jordi Boget, Teresa Pons, Francesca Lomeña, Francisco Ros, Domènec Pavía, Javier Setoain, Xavier |
author_sort | Perissinotti, Andrés |
collection | PubMed |
description | PURPOSE: We present a modified version of the SISCOM procedure that uses interictal PET instead of interictal SPECT for seizure onset zone localization. We called this new nuclear imaging processing technique PISCOM (PET interictal subtracted ictal SPECT coregistered with MRI). METHODS: We retrospectively studied 23 patients (age range 4–61 years) with medically refractory epilepsy who had undergone MRI, ictal SPECT, interictal SPECT and interictal FDG PET and who had been seizure-free for at least 2 years after surgical treatment. FDG PET images were reprocessed (rFDG PET) to assimilate SPECT features for image subtraction. Interictal SPECT and rFDG PET were compared using statistical parametric mapping (SPM). PISCOM and SISCOM images were evaluated visually and using an automated volume of interest-based analysis. The results of the two studies were compared with each other and with the known surgical resection site. RESULTS: SPM showed no significant differences in cortical activity between SPECT and rFDG PET images. PISCOM and SISCOM showed equivalent results in 17 of 23 patients (74%). The seizure onset zone was successfully identified in 19 patients (83%) by PISCOM and in 17 (74%) by SISCOM: in 15 patients (65%) the two techniques showed concordant successful results. The volume of interest-based analysis showed no significant differences between PISCOM and SISCOM in identifying the extension of the seizure onset zone. However, PISCOM showed a lower amount of indeterminate activity due to propagation, background or artefacts. CONCLUSION: Preliminary findings of this initial proof-of-concept study suggest that perfusion and glucose metabolism in the cerebral cortex can be correlated and that PISCOM may be a valid technique for identification of the seizure onset zone. However, further studies are needed to validate these results. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00259-018-4080-6) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6208811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-62088112018-11-09 PISCOM: a new procedure for epilepsy combining ictal SPECT and interictal PET Perissinotti, Andrés Niñerola-Baizán, Aida Rubí, Sebastià Carreño, Mar Marti-Fuster, Berta Aparicio, Javier Mayoral, Maria Donaire, Antonio Sanchez-Izquierdo, Nuria Bargalló, Nuria Rumiá, Jordi Boget, Teresa Pons, Francesca Lomeña, Francisco Ros, Domènec Pavía, Javier Setoain, Xavier Eur J Nucl Med Mol Imaging Original Article PURPOSE: We present a modified version of the SISCOM procedure that uses interictal PET instead of interictal SPECT for seizure onset zone localization. We called this new nuclear imaging processing technique PISCOM (PET interictal subtracted ictal SPECT coregistered with MRI). METHODS: We retrospectively studied 23 patients (age range 4–61 years) with medically refractory epilepsy who had undergone MRI, ictal SPECT, interictal SPECT and interictal FDG PET and who had been seizure-free for at least 2 years after surgical treatment. FDG PET images were reprocessed (rFDG PET) to assimilate SPECT features for image subtraction. Interictal SPECT and rFDG PET were compared using statistical parametric mapping (SPM). PISCOM and SISCOM images were evaluated visually and using an automated volume of interest-based analysis. The results of the two studies were compared with each other and with the known surgical resection site. RESULTS: SPM showed no significant differences in cortical activity between SPECT and rFDG PET images. PISCOM and SISCOM showed equivalent results in 17 of 23 patients (74%). The seizure onset zone was successfully identified in 19 patients (83%) by PISCOM and in 17 (74%) by SISCOM: in 15 patients (65%) the two techniques showed concordant successful results. The volume of interest-based analysis showed no significant differences between PISCOM and SISCOM in identifying the extension of the seizure onset zone. However, PISCOM showed a lower amount of indeterminate activity due to propagation, background or artefacts. CONCLUSION: Preliminary findings of this initial proof-of-concept study suggest that perfusion and glucose metabolism in the cerebral cortex can be correlated and that PISCOM may be a valid technique for identification of the seizure onset zone. However, further studies are needed to validate these results. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00259-018-4080-6) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2018-08-01 2018 /pmc/articles/PMC6208811/ /pubmed/30069576 http://dx.doi.org/10.1007/s00259-018-4080-6 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Perissinotti, Andrés Niñerola-Baizán, Aida Rubí, Sebastià Carreño, Mar Marti-Fuster, Berta Aparicio, Javier Mayoral, Maria Donaire, Antonio Sanchez-Izquierdo, Nuria Bargalló, Nuria Rumiá, Jordi Boget, Teresa Pons, Francesca Lomeña, Francisco Ros, Domènec Pavía, Javier Setoain, Xavier PISCOM: a new procedure for epilepsy combining ictal SPECT and interictal PET |
title | PISCOM: a new procedure for epilepsy combining ictal SPECT and interictal PET |
title_full | PISCOM: a new procedure for epilepsy combining ictal SPECT and interictal PET |
title_fullStr | PISCOM: a new procedure for epilepsy combining ictal SPECT and interictal PET |
title_full_unstemmed | PISCOM: a new procedure for epilepsy combining ictal SPECT and interictal PET |
title_short | PISCOM: a new procedure for epilepsy combining ictal SPECT and interictal PET |
title_sort | piscom: a new procedure for epilepsy combining ictal spect and interictal pet |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208811/ https://www.ncbi.nlm.nih.gov/pubmed/30069576 http://dx.doi.org/10.1007/s00259-018-4080-6 |
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