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Percutaneous ozone nucleolysis for lumbar disc herniation
PURPOSE: All percutaneous minimally invasive disc treatments are typically indicated to contained disc herniations. Our study’s aim is to evaluate prospectively the efficacy of ozone nucleolysis in the treatment of either contained or uncontained lumbar disc herniations. METHODS: Fifty-two patients,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208962/ https://www.ncbi.nlm.nih.gov/pubmed/30206674 http://dx.doi.org/10.1007/s00234-018-2083-4 |
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author | Ezeldin, Mohamed Leonardi, Marco Princiotta, Ciro Dall’olio, Massimo Tharwat, Mohammed Zaki, Mohammed Abdel-Wanis, Mohamed E. Cirillo, Luigi |
author_facet | Ezeldin, Mohamed Leonardi, Marco Princiotta, Ciro Dall’olio, Massimo Tharwat, Mohammed Zaki, Mohammed Abdel-Wanis, Mohamed E. Cirillo, Luigi |
author_sort | Ezeldin, Mohamed |
collection | PubMed |
description | PURPOSE: All percutaneous minimally invasive disc treatments are typically indicated to contained disc herniations. Our study’s aim is to evaluate prospectively the efficacy of ozone nucleolysis in the treatment of either contained or uncontained lumbar disc herniations. METHODS: Fifty-two patients, aged 27–87 years, with symptomatic herniated lumbar discs, without migration, sequestration, or severe degenerative disc changes, who failed conservative treatment, were included in our study. The patients underwent fluoroscopic-guided intradiscal oxygen-ozone mixture injection (5 ml) at a concentration of 27–30 μg/ml and periradicular injection of the same O(2)-O(3) mixture (10 ml), steroid (1 ml), and local anesthetic (1 ml). Clinical outcomes were evaluated, based on the Oswestry Disability Index (ODI) and pain intensity (0–5) scale results, obtained initially and at 2- and 6-month controls. Our results were analyzed by ANOVA and chi-squared (χ(2)) tests. RESULTS: Our initial results obtained at 2-month control were promising, indicating a significant decrease in pain disability and intensity in 74% (37) and 76% (38) of the patients respectively, and minimally increased to 76% (38) and 78% (39) at 6-month control (P < 0.001 and CI 99.9%). The mean preprocedure ODI and pain intensity scores were 35 ± 14.36 and 2.38 ± 0.90, respectively, which were reduced to 19.36 ± 13.12 and 1.04 ± 0.92 at 6-month control. Our failure had been mostly related to long symptoms duration of more than 1 year. No complications were recorded. CONCLUSION: Ozone nucleolysis is a safe cost-effective minimally invasive technique for treatment of contained and uncontained lumbar disc herniations. |
format | Online Article Text |
id | pubmed-6208962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-62089622018-11-09 Percutaneous ozone nucleolysis for lumbar disc herniation Ezeldin, Mohamed Leonardi, Marco Princiotta, Ciro Dall’olio, Massimo Tharwat, Mohammed Zaki, Mohammed Abdel-Wanis, Mohamed E. Cirillo, Luigi Neuroradiology Interventional Neuroradiology PURPOSE: All percutaneous minimally invasive disc treatments are typically indicated to contained disc herniations. Our study’s aim is to evaluate prospectively the efficacy of ozone nucleolysis in the treatment of either contained or uncontained lumbar disc herniations. METHODS: Fifty-two patients, aged 27–87 years, with symptomatic herniated lumbar discs, without migration, sequestration, or severe degenerative disc changes, who failed conservative treatment, were included in our study. The patients underwent fluoroscopic-guided intradiscal oxygen-ozone mixture injection (5 ml) at a concentration of 27–30 μg/ml and periradicular injection of the same O(2)-O(3) mixture (10 ml), steroid (1 ml), and local anesthetic (1 ml). Clinical outcomes were evaluated, based on the Oswestry Disability Index (ODI) and pain intensity (0–5) scale results, obtained initially and at 2- and 6-month controls. Our results were analyzed by ANOVA and chi-squared (χ(2)) tests. RESULTS: Our initial results obtained at 2-month control were promising, indicating a significant decrease in pain disability and intensity in 74% (37) and 76% (38) of the patients respectively, and minimally increased to 76% (38) and 78% (39) at 6-month control (P < 0.001 and CI 99.9%). The mean preprocedure ODI and pain intensity scores were 35 ± 14.36 and 2.38 ± 0.90, respectively, which were reduced to 19.36 ± 13.12 and 1.04 ± 0.92 at 6-month control. Our failure had been mostly related to long symptoms duration of more than 1 year. No complications were recorded. CONCLUSION: Ozone nucleolysis is a safe cost-effective minimally invasive technique for treatment of contained and uncontained lumbar disc herniations. Springer Berlin Heidelberg 2018-09-11 2018 /pmc/articles/PMC6208962/ /pubmed/30206674 http://dx.doi.org/10.1007/s00234-018-2083-4 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Interventional Neuroradiology Ezeldin, Mohamed Leonardi, Marco Princiotta, Ciro Dall’olio, Massimo Tharwat, Mohammed Zaki, Mohammed Abdel-Wanis, Mohamed E. Cirillo, Luigi Percutaneous ozone nucleolysis for lumbar disc herniation |
title | Percutaneous ozone nucleolysis for lumbar disc herniation |
title_full | Percutaneous ozone nucleolysis for lumbar disc herniation |
title_fullStr | Percutaneous ozone nucleolysis for lumbar disc herniation |
title_full_unstemmed | Percutaneous ozone nucleolysis for lumbar disc herniation |
title_short | Percutaneous ozone nucleolysis for lumbar disc herniation |
title_sort | percutaneous ozone nucleolysis for lumbar disc herniation |
topic | Interventional Neuroradiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208962/ https://www.ncbi.nlm.nih.gov/pubmed/30206674 http://dx.doi.org/10.1007/s00234-018-2083-4 |
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