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Electrodiffusion-Mediated Swelling of a Two-Phase Gel Model of Gastric Mucus

Gastric mucus gel is known to exhibit dramatic and unique swelling behaviors in response to the ionic composition of the hydrating solution. This swelling behavior is important in the maintenance of the mucus layer lining the stomach wall, as the layer is constantly digested by enzymes in the lumen,...

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Autores principales: Lewis, Owen L., Keener, James P., Fogelson, Aaron L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209243/
https://www.ncbi.nlm.nih.gov/pubmed/30674852
http://dx.doi.org/10.3390/gels4030076
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author Lewis, Owen L.
Keener, James P.
Fogelson, Aaron L.
author_facet Lewis, Owen L.
Keener, James P.
Fogelson, Aaron L.
author_sort Lewis, Owen L.
collection PubMed
description Gastric mucus gel is known to exhibit dramatic and unique swelling behaviors in response to the ionic composition of the hydrating solution. This swelling behavior is important in the maintenance of the mucus layer lining the stomach wall, as the layer is constantly digested by enzymes in the lumen, and must be replenished by new mucus that swells as it is secreted from the gastric wall. One hypothesis suggests that the condensed state of mucus at secretion is maintained by transient bonds with calcium that form crosslinks. These crosslinks are lost as monovalent cations from the environment displace divalent crosslinkers, leading to a dramatic change in the energy of the gel and inducing the swelling behavior. Previous modeling work has characterized the equilibrium behavior of polyelectrolyte gels that respond to calcium crosslinking. Here, we present an investigation of the dynamic swelling behavior of a polyelectrolytic gel model of mucus. In particular, we quantified the rate at which a globule of initially crosslinked gel swells when exposed to an ionic bath. The dependence of this swelling rate on several parameters was characterized. We observed that swelling rate has a non-monotone dependence on the molarity of the bath solution, with moderate concentrations of available sodium inducing the fastest swelling.
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spelling pubmed-62092432019-01-17 Electrodiffusion-Mediated Swelling of a Two-Phase Gel Model of Gastric Mucus Lewis, Owen L. Keener, James P. Fogelson, Aaron L. Gels Article Gastric mucus gel is known to exhibit dramatic and unique swelling behaviors in response to the ionic composition of the hydrating solution. This swelling behavior is important in the maintenance of the mucus layer lining the stomach wall, as the layer is constantly digested by enzymes in the lumen, and must be replenished by new mucus that swells as it is secreted from the gastric wall. One hypothesis suggests that the condensed state of mucus at secretion is maintained by transient bonds with calcium that form crosslinks. These crosslinks are lost as monovalent cations from the environment displace divalent crosslinkers, leading to a dramatic change in the energy of the gel and inducing the swelling behavior. Previous modeling work has characterized the equilibrium behavior of polyelectrolyte gels that respond to calcium crosslinking. Here, we present an investigation of the dynamic swelling behavior of a polyelectrolytic gel model of mucus. In particular, we quantified the rate at which a globule of initially crosslinked gel swells when exposed to an ionic bath. The dependence of this swelling rate on several parameters was characterized. We observed that swelling rate has a non-monotone dependence on the molarity of the bath solution, with moderate concentrations of available sodium inducing the fastest swelling. MDPI 2018-09-06 /pmc/articles/PMC6209243/ /pubmed/30674852 http://dx.doi.org/10.3390/gels4030076 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lewis, Owen L.
Keener, James P.
Fogelson, Aaron L.
Electrodiffusion-Mediated Swelling of a Two-Phase Gel Model of Gastric Mucus
title Electrodiffusion-Mediated Swelling of a Two-Phase Gel Model of Gastric Mucus
title_full Electrodiffusion-Mediated Swelling of a Two-Phase Gel Model of Gastric Mucus
title_fullStr Electrodiffusion-Mediated Swelling of a Two-Phase Gel Model of Gastric Mucus
title_full_unstemmed Electrodiffusion-Mediated Swelling of a Two-Phase Gel Model of Gastric Mucus
title_short Electrodiffusion-Mediated Swelling of a Two-Phase Gel Model of Gastric Mucus
title_sort electrodiffusion-mediated swelling of a two-phase gel model of gastric mucus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209243/
https://www.ncbi.nlm.nih.gov/pubmed/30674852
http://dx.doi.org/10.3390/gels4030076
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