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Genetic association study of dyslexia and ADHD candidate genes in a Spanish cohort: Implications of comorbid samples
Dyslexia and attention deficit hyperactivity disorder (ADHD) are two complex neuro-behaviorally disorders that co-occur more often than expected, so that reading disability has been linked to inattention symptoms. We examined 4 SNPs located on genes previously associated to dyslexia (KIAA0319, DCDC2...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209299/ https://www.ncbi.nlm.nih.gov/pubmed/30379906 http://dx.doi.org/10.1371/journal.pone.0206431 |
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author | Sánchez-Morán, Mirian Hernández, Juan Andrés Duñabeitia, Jon Andoni Estévez, Adelina Bárcena, Laura González-Lahera, Aintzane Bajo, María Teresa Fuentes, Luis J. Aransay, Ana M. Carreiras, Manuel |
author_facet | Sánchez-Morán, Mirian Hernández, Juan Andrés Duñabeitia, Jon Andoni Estévez, Adelina Bárcena, Laura González-Lahera, Aintzane Bajo, María Teresa Fuentes, Luis J. Aransay, Ana M. Carreiras, Manuel |
author_sort | Sánchez-Morán, Mirian |
collection | PubMed |
description | Dyslexia and attention deficit hyperactivity disorder (ADHD) are two complex neuro-behaviorally disorders that co-occur more often than expected, so that reading disability has been linked to inattention symptoms. We examined 4 SNPs located on genes previously associated to dyslexia (KIAA0319, DCDC2, DYX1C1 and FOXP2) and 3 SNPs within genes related to ADHD (COMT, MAOA and DBH) in a cohort of Spanish children (N = 2078) that met the criteria of having one, both or none of these disorders (dyslexia and ADHD). We used a case-control approach comparing different groups of samples based on each individual diagnosis. In addition, we also performed a quantitative trait analysis with psychometric measures on the general population (N = 3357). The results indicated that the significance values for some markers change depending on the phenotypic groups compared and/or when considering pair-wise marker interactions. Furthermore, our quantitative trait study showed significant genetic associations with specific cognitive processes. These outcomes advocate the importance of establishing rigorous and homogeneous criteria for the diagnosis of cognitive disorders, as well as the relevance of considering cognitive endophenotypes. |
format | Online Article Text |
id | pubmed-6209299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-62092992018-11-19 Genetic association study of dyslexia and ADHD candidate genes in a Spanish cohort: Implications of comorbid samples Sánchez-Morán, Mirian Hernández, Juan Andrés Duñabeitia, Jon Andoni Estévez, Adelina Bárcena, Laura González-Lahera, Aintzane Bajo, María Teresa Fuentes, Luis J. Aransay, Ana M. Carreiras, Manuel PLoS One Research Article Dyslexia and attention deficit hyperactivity disorder (ADHD) are two complex neuro-behaviorally disorders that co-occur more often than expected, so that reading disability has been linked to inattention symptoms. We examined 4 SNPs located on genes previously associated to dyslexia (KIAA0319, DCDC2, DYX1C1 and FOXP2) and 3 SNPs within genes related to ADHD (COMT, MAOA and DBH) in a cohort of Spanish children (N = 2078) that met the criteria of having one, both or none of these disorders (dyslexia and ADHD). We used a case-control approach comparing different groups of samples based on each individual diagnosis. In addition, we also performed a quantitative trait analysis with psychometric measures on the general population (N = 3357). The results indicated that the significance values for some markers change depending on the phenotypic groups compared and/or when considering pair-wise marker interactions. Furthermore, our quantitative trait study showed significant genetic associations with specific cognitive processes. These outcomes advocate the importance of establishing rigorous and homogeneous criteria for the diagnosis of cognitive disorders, as well as the relevance of considering cognitive endophenotypes. Public Library of Science 2018-10-31 /pmc/articles/PMC6209299/ /pubmed/30379906 http://dx.doi.org/10.1371/journal.pone.0206431 Text en © 2018 Sánchez-Morán et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sánchez-Morán, Mirian Hernández, Juan Andrés Duñabeitia, Jon Andoni Estévez, Adelina Bárcena, Laura González-Lahera, Aintzane Bajo, María Teresa Fuentes, Luis J. Aransay, Ana M. Carreiras, Manuel Genetic association study of dyslexia and ADHD candidate genes in a Spanish cohort: Implications of comorbid samples |
title | Genetic association study of dyslexia and ADHD candidate genes in a Spanish cohort: Implications of comorbid samples |
title_full | Genetic association study of dyslexia and ADHD candidate genes in a Spanish cohort: Implications of comorbid samples |
title_fullStr | Genetic association study of dyslexia and ADHD candidate genes in a Spanish cohort: Implications of comorbid samples |
title_full_unstemmed | Genetic association study of dyslexia and ADHD candidate genes in a Spanish cohort: Implications of comorbid samples |
title_short | Genetic association study of dyslexia and ADHD candidate genes in a Spanish cohort: Implications of comorbid samples |
title_sort | genetic association study of dyslexia and adhd candidate genes in a spanish cohort: implications of comorbid samples |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209299/ https://www.ncbi.nlm.nih.gov/pubmed/30379906 http://dx.doi.org/10.1371/journal.pone.0206431 |
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