Cargando…
Calcific tendinopathy of the shoulder: clinical perspectives into the mechanisms, pathogenesis, and treatment
Calcific tendinopathy (CT) of the shoulder is a common, painful condition characterized by the presence of calcium deposits in the rotator cuff tendons. Current theories indicate that CT may be the result of a cell-mediated process in which, after a stage of calcium deposition, calcifications are sp...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209365/ https://www.ncbi.nlm.nih.gov/pubmed/30774461 http://dx.doi.org/10.2147/ORR.S138225 |
_version_ | 1783366898759499776 |
---|---|
author | Sansone, Valerio Maiorano, Emanuele Galluzzo, Alessandro Pascale, Valerio |
author_facet | Sansone, Valerio Maiorano, Emanuele Galluzzo, Alessandro Pascale, Valerio |
author_sort | Sansone, Valerio |
collection | PubMed |
description | Calcific tendinopathy (CT) of the shoulder is a common, painful condition characterized by the presence of calcium deposits in the rotator cuff tendons. Current theories indicate that CT may be the result of a cell-mediated process in which, after a stage of calcium deposition, calcifications are spontaneously resorbed. However, in a minority of cases, this self-healing process is somehow disrupted, resulting in symptoms. Recent literature shows an emerging role of biological and genetic factors underlying CT. This new evidence could supplement the classic mechanical theory of rotator cuff tendinopathy complicated by calcium precipitation, and it may also explain why the majority of the therapies currently in use are only able to provide partially satisfactory outcomes. This review aims to summarize the current knowledge about the pathological processes underlying CT of the shoulder and thereby justify the quest for advanced biological treatments of this condition when it becomes symptomatic. |
format | Online Article Text |
id | pubmed-6209365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-62093652019-02-15 Calcific tendinopathy of the shoulder: clinical perspectives into the mechanisms, pathogenesis, and treatment Sansone, Valerio Maiorano, Emanuele Galluzzo, Alessandro Pascale, Valerio Orthop Res Rev Review Calcific tendinopathy (CT) of the shoulder is a common, painful condition characterized by the presence of calcium deposits in the rotator cuff tendons. Current theories indicate that CT may be the result of a cell-mediated process in which, after a stage of calcium deposition, calcifications are spontaneously resorbed. However, in a minority of cases, this self-healing process is somehow disrupted, resulting in symptoms. Recent literature shows an emerging role of biological and genetic factors underlying CT. This new evidence could supplement the classic mechanical theory of rotator cuff tendinopathy complicated by calcium precipitation, and it may also explain why the majority of the therapies currently in use are only able to provide partially satisfactory outcomes. This review aims to summarize the current knowledge about the pathological processes underlying CT of the shoulder and thereby justify the quest for advanced biological treatments of this condition when it becomes symptomatic. Dove Medical Press 2018-10-03 /pmc/articles/PMC6209365/ /pubmed/30774461 http://dx.doi.org/10.2147/ORR.S138225 Text en © 2018 Sansone et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Sansone, Valerio Maiorano, Emanuele Galluzzo, Alessandro Pascale, Valerio Calcific tendinopathy of the shoulder: clinical perspectives into the mechanisms, pathogenesis, and treatment |
title | Calcific tendinopathy of the shoulder: clinical perspectives into the mechanisms, pathogenesis, and treatment |
title_full | Calcific tendinopathy of the shoulder: clinical perspectives into the mechanisms, pathogenesis, and treatment |
title_fullStr | Calcific tendinopathy of the shoulder: clinical perspectives into the mechanisms, pathogenesis, and treatment |
title_full_unstemmed | Calcific tendinopathy of the shoulder: clinical perspectives into the mechanisms, pathogenesis, and treatment |
title_short | Calcific tendinopathy of the shoulder: clinical perspectives into the mechanisms, pathogenesis, and treatment |
title_sort | calcific tendinopathy of the shoulder: clinical perspectives into the mechanisms, pathogenesis, and treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209365/ https://www.ncbi.nlm.nih.gov/pubmed/30774461 http://dx.doi.org/10.2147/ORR.S138225 |
work_keys_str_mv | AT sansonevalerio calcifictendinopathyoftheshoulderclinicalperspectivesintothemechanismspathogenesisandtreatment AT maioranoemanuele calcifictendinopathyoftheshoulderclinicalperspectivesintothemechanismspathogenesisandtreatment AT galluzzoalessandro calcifictendinopathyoftheshoulderclinicalperspectivesintothemechanismspathogenesisandtreatment AT pascalevalerio calcifictendinopathyoftheshoulderclinicalperspectivesintothemechanismspathogenesisandtreatment |