Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma

A methionine substitution at lysine-27 on histone H3 variants (H3K27M) characterizes ~80% of diffuse intrinsic pontine gliomas (DIPG) and inhibits polycomb repressive complex 2 (PRC2) in a dominant-negative fashion. Yet, the mechanisms for this inhibition and abnormal epigenomic landscape have not b...

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Detalles Bibliográficos
Autores principales: Stafford, James M., Lee, Chul-Hwan, Voigt, Philipp, Descostes, Nicolas, Saldaña-Meyer, Ricardo, Yu, Jia-Ray, Leroy, Gary, Oksuz, Ozgur, Chapman, Jessica R., Suarez, Fernando, Modrek, Aram S., Bayin, N. Sumru, Placantonakis, Dimitris G., Karajannis, Matthias A., Snuderl, Matija, Ueberheide, Beatrix, Reinberg, Danny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209383/
https://www.ncbi.nlm.nih.gov/pubmed/30402543
http://dx.doi.org/10.1126/sciadv.aau5935

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