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Bakuchiol protects against pathological cardiac hypertrophy by blocking NF-κB signaling pathway

Bakuchiol (Bak), a monoterpene phenol isolated from the seeds of Psoralea corylifolia, has been widely used to treat a large variety of diseases in both Indian and Chinese folkloric medicine. However, the effects of Bak on cardiac hypertrophy remain unclear. Therefore, the present study was designed...

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Autores principales: Wang, Zheng, Gao, Lu, Xiao, Lili, Kong, Lingyao, Shi, Huiting, Tian, Xinyu, Zhao, Luosha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209581/
https://www.ncbi.nlm.nih.gov/pubmed/30242058
http://dx.doi.org/10.1042/BSR20181043
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author Wang, Zheng
Gao, Lu
Xiao, Lili
Kong, Lingyao
Shi, Huiting
Tian, Xinyu
Zhao, Luosha
author_facet Wang, Zheng
Gao, Lu
Xiao, Lili
Kong, Lingyao
Shi, Huiting
Tian, Xinyu
Zhao, Luosha
author_sort Wang, Zheng
collection PubMed
description Bakuchiol (Bak), a monoterpene phenol isolated from the seeds of Psoralea corylifolia, has been widely used to treat a large variety of diseases in both Indian and Chinese folkloric medicine. However, the effects of Bak on cardiac hypertrophy remain unclear. Therefore, the present study was designed to determine whether Bak could alleviate cardiac hypertrophy. Mice were subjected to aortic banding (AB) to induce cardiac hypertrophy model. Bak of 1 ml/100 g body weight was given by oral gavage once a day from 1 to 8 weeks after surgery. Our data demonstrated for the first time that Bak could attenuate pressure overload-induced cardiac hypertrophy and could attenuate fibrosis and the inflammatory response induced by AB. The results further revealed that the effect of Bak on cardiac hypertrophy was mediated by blocking the activation of the NF-κB signaling pathway. In vitro studies performed in neonatal rat cardiomyocytes further proved that the protective effect of Bak on cardiac hypertrophy is largely dependent on the NF-κB pathway. Based on our results, Bak shows profound potential for its application in the treatment of pathological cardiac hypertrophy, and we believe that Bak may be a promising therapeutic candidate to treat cardiac hypertrophy and heart failure.
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spelling pubmed-62095812018-11-14 Bakuchiol protects against pathological cardiac hypertrophy by blocking NF-κB signaling pathway Wang, Zheng Gao, Lu Xiao, Lili Kong, Lingyao Shi, Huiting Tian, Xinyu Zhao, Luosha Biosci Rep Research Articles Bakuchiol (Bak), a monoterpene phenol isolated from the seeds of Psoralea corylifolia, has been widely used to treat a large variety of diseases in both Indian and Chinese folkloric medicine. However, the effects of Bak on cardiac hypertrophy remain unclear. Therefore, the present study was designed to determine whether Bak could alleviate cardiac hypertrophy. Mice were subjected to aortic banding (AB) to induce cardiac hypertrophy model. Bak of 1 ml/100 g body weight was given by oral gavage once a day from 1 to 8 weeks after surgery. Our data demonstrated for the first time that Bak could attenuate pressure overload-induced cardiac hypertrophy and could attenuate fibrosis and the inflammatory response induced by AB. The results further revealed that the effect of Bak on cardiac hypertrophy was mediated by blocking the activation of the NF-κB signaling pathway. In vitro studies performed in neonatal rat cardiomyocytes further proved that the protective effect of Bak on cardiac hypertrophy is largely dependent on the NF-κB pathway. Based on our results, Bak shows profound potential for its application in the treatment of pathological cardiac hypertrophy, and we believe that Bak may be a promising therapeutic candidate to treat cardiac hypertrophy and heart failure. Portland Press Ltd. 2018-10-31 /pmc/articles/PMC6209581/ /pubmed/30242058 http://dx.doi.org/10.1042/BSR20181043 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Wang, Zheng
Gao, Lu
Xiao, Lili
Kong, Lingyao
Shi, Huiting
Tian, Xinyu
Zhao, Luosha
Bakuchiol protects against pathological cardiac hypertrophy by blocking NF-κB signaling pathway
title Bakuchiol protects against pathological cardiac hypertrophy by blocking NF-κB signaling pathway
title_full Bakuchiol protects against pathological cardiac hypertrophy by blocking NF-κB signaling pathway
title_fullStr Bakuchiol protects against pathological cardiac hypertrophy by blocking NF-κB signaling pathway
title_full_unstemmed Bakuchiol protects against pathological cardiac hypertrophy by blocking NF-κB signaling pathway
title_short Bakuchiol protects against pathological cardiac hypertrophy by blocking NF-κB signaling pathway
title_sort bakuchiol protects against pathological cardiac hypertrophy by blocking nf-κb signaling pathway
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209581/
https://www.ncbi.nlm.nih.gov/pubmed/30242058
http://dx.doi.org/10.1042/BSR20181043
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