The potential roles of circRNAs in osteoarthritis: a coming journey to find a treasure

Osteoarthritis (OA), a common joint disease in elderly, causes serious social and economic burdens worldwide. Previous studies indicated that some differentially expressed circular RNAs (circRNAs) participated in the initiation and progression of OA. These findings suggested that circRNAs may act as...

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Detalles Bibliográficos
Autores principales: Li, Hui-Zi, Lin, Zhong, Xu, Xiang-He, Lin, Nan, Lu, Hua-Ding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209588/
https://www.ncbi.nlm.nih.gov/pubmed/30279209
http://dx.doi.org/10.1042/BSR20180542
Descripción
Sumario:Osteoarthritis (OA), a common joint disease in elderly, causes serious social and economic burdens worldwide. Previous studies indicated that some differentially expressed circular RNAs (circRNAs) participated in the initiation and progression of OA. These findings suggested that circRNAs may act as promising diagnostic biomarkers and therapeutic targets for OA. In this review, we summarize the biogenesis and biological functions of circRNAs and explore the underlying roles of circRNAs in OA, which may enlighten further studies and contribute to the early diagnosis and intervention of OA.

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