The potential roles of circRNAs in osteoarthritis: a coming journey to find a treasure

Osteoarthritis (OA), a common joint disease in elderly, causes serious social and economic burdens worldwide. Previous studies indicated that some differentially expressed circular RNAs (circRNAs) participated in the initiation and progression of OA. These findings suggested that circRNAs may act as...

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Autores principales: Li, Hui-Zi, Lin, Zhong, Xu, Xiang-He, Lin, Nan, Lu, Hua-Ding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209588/
https://www.ncbi.nlm.nih.gov/pubmed/30279209
http://dx.doi.org/10.1042/BSR20180542
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author Li, Hui-Zi
Lin, Zhong
Xu, Xiang-He
Lin, Nan
Lu, Hua-Ding
author_facet Li, Hui-Zi
Lin, Zhong
Xu, Xiang-He
Lin, Nan
Lu, Hua-Ding
author_sort Li, Hui-Zi
collection PubMed
description Osteoarthritis (OA), a common joint disease in elderly, causes serious social and economic burdens worldwide. Previous studies indicated that some differentially expressed circular RNAs (circRNAs) participated in the initiation and progression of OA. These findings suggested that circRNAs may act as promising diagnostic biomarkers and therapeutic targets for OA. In this review, we summarize the biogenesis and biological functions of circRNAs and explore the underlying roles of circRNAs in OA, which may enlighten further studies and contribute to the early diagnosis and intervention of OA.
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spelling pubmed-62095882018-11-14 The potential roles of circRNAs in osteoarthritis: a coming journey to find a treasure Li, Hui-Zi Lin, Zhong Xu, Xiang-He Lin, Nan Lu, Hua-Ding Biosci Rep Review Articles Osteoarthritis (OA), a common joint disease in elderly, causes serious social and economic burdens worldwide. Previous studies indicated that some differentially expressed circular RNAs (circRNAs) participated in the initiation and progression of OA. These findings suggested that circRNAs may act as promising diagnostic biomarkers and therapeutic targets for OA. In this review, we summarize the biogenesis and biological functions of circRNAs and explore the underlying roles of circRNAs in OA, which may enlighten further studies and contribute to the early diagnosis and intervention of OA. Portland Press Ltd. 2018-10-31 /pmc/articles/PMC6209588/ /pubmed/30279209 http://dx.doi.org/10.1042/BSR20180542 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Li, Hui-Zi
Lin, Zhong
Xu, Xiang-He
Lin, Nan
Lu, Hua-Ding
The potential roles of circRNAs in osteoarthritis: a coming journey to find a treasure
title The potential roles of circRNAs in osteoarthritis: a coming journey to find a treasure
title_full The potential roles of circRNAs in osteoarthritis: a coming journey to find a treasure
title_fullStr The potential roles of circRNAs in osteoarthritis: a coming journey to find a treasure
title_full_unstemmed The potential roles of circRNAs in osteoarthritis: a coming journey to find a treasure
title_short The potential roles of circRNAs in osteoarthritis: a coming journey to find a treasure
title_sort potential roles of circrnas in osteoarthritis: a coming journey to find a treasure
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209588/
https://www.ncbi.nlm.nih.gov/pubmed/30279209
http://dx.doi.org/10.1042/BSR20180542
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