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A pediatric case of anaphylactic shock induced by tipepidine hibenzate (Asverin)
Tipepidine hibenzate (Asverin) is commonly used as an antitussive drug for acute and chronic cough in various age groups and is generally safe and well-tolerated. However, we experienced a case of tipepidine hibenzate-induced anaphylactic shock in a 1-year-old boy. After ingesting cold medication in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asia Pacific Association of Allergy, Asthma and Clinical Immunology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209596/ https://www.ncbi.nlm.nih.gov/pubmed/30402404 http://dx.doi.org/10.5415/apallergy.2018.8.e37 |
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author | Takai, Hirotake Kato, Izumi Mitsunaga, Kanako Hara, Mayumi Kodama, Takahiro Kanazawa, Masaki Terai, Masaru |
author_facet | Takai, Hirotake Kato, Izumi Mitsunaga, Kanako Hara, Mayumi Kodama, Takahiro Kanazawa, Masaki Terai, Masaru |
author_sort | Takai, Hirotake |
collection | PubMed |
description | Tipepidine hibenzate (Asverin) is commonly used as an antitussive drug for acute and chronic cough in various age groups and is generally safe and well-tolerated. However, we experienced a case of tipepidine hibenzate-induced anaphylactic shock in a 1-year-old boy. After ingesting cold medication including tipepidine hibenzate, the patient presented with generalized erythema and urticaria, swollen face, coughing, wheezing and vomiting, together with hypotension and a decreased level of consciousness. To identify the culprit drug, we performed skin prick tests (SPTs) and oral drug provocation tests (DPTs). SPTs revealed a negative reaction for all drugs, but DPTs caused a positive reaction only for a full therapeutic dose of tipepidine hibenzate. Physicians need to consider tipepidine hibezate as a culprit drug when anaphylaxis occurs after taking anticough or common cold medication. |
format | Online Article Text |
id | pubmed-6209596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Asia Pacific Association of Allergy, Asthma and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-62095962018-11-06 A pediatric case of anaphylactic shock induced by tipepidine hibenzate (Asverin) Takai, Hirotake Kato, Izumi Mitsunaga, Kanako Hara, Mayumi Kodama, Takahiro Kanazawa, Masaki Terai, Masaru Asia Pac Allergy Case Report Tipepidine hibenzate (Asverin) is commonly used as an antitussive drug for acute and chronic cough in various age groups and is generally safe and well-tolerated. However, we experienced a case of tipepidine hibenzate-induced anaphylactic shock in a 1-year-old boy. After ingesting cold medication including tipepidine hibenzate, the patient presented with generalized erythema and urticaria, swollen face, coughing, wheezing and vomiting, together with hypotension and a decreased level of consciousness. To identify the culprit drug, we performed skin prick tests (SPTs) and oral drug provocation tests (DPTs). SPTs revealed a negative reaction for all drugs, but DPTs caused a positive reaction only for a full therapeutic dose of tipepidine hibenzate. Physicians need to consider tipepidine hibezate as a culprit drug when anaphylaxis occurs after taking anticough or common cold medication. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2018-10-18 /pmc/articles/PMC6209596/ /pubmed/30402404 http://dx.doi.org/10.5415/apallergy.2018.8.e37 Text en Copyright © 2018. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Takai, Hirotake Kato, Izumi Mitsunaga, Kanako Hara, Mayumi Kodama, Takahiro Kanazawa, Masaki Terai, Masaru A pediatric case of anaphylactic shock induced by tipepidine hibenzate (Asverin) |
title | A pediatric case of anaphylactic shock induced by tipepidine hibenzate (Asverin) |
title_full | A pediatric case of anaphylactic shock induced by tipepidine hibenzate (Asverin) |
title_fullStr | A pediatric case of anaphylactic shock induced by tipepidine hibenzate (Asverin) |
title_full_unstemmed | A pediatric case of anaphylactic shock induced by tipepidine hibenzate (Asverin) |
title_short | A pediatric case of anaphylactic shock induced by tipepidine hibenzate (Asverin) |
title_sort | pediatric case of anaphylactic shock induced by tipepidine hibenzate (asverin) |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209596/ https://www.ncbi.nlm.nih.gov/pubmed/30402404 http://dx.doi.org/10.5415/apallergy.2018.8.e37 |
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