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Genetic polymorphisms of MBL2 and tuberculosis susceptibility: a meta-analysis of 22 case-control studies
INTRODUCTION: The association of mannose-binding lectin gene (MBL2) polymorphisms with tuberculosis susceptibility was inconclusive. In this study, a meta-analysis of 22 case-control studies was carried out to assess the effect of MBL2 polymorphisms on tuberculosis risk. MATERIAL AND METHODS: A sear...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209707/ https://www.ncbi.nlm.nih.gov/pubmed/30393476 http://dx.doi.org/10.5114/aoms.2017.65319 |
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author | Cao, Yan Wang, Xinjing Cao, Zhihong Wu, Chunyan Wu, Dongmei Cheng, Xiaoxing |
author_facet | Cao, Yan Wang, Xinjing Cao, Zhihong Wu, Chunyan Wu, Dongmei Cheng, Xiaoxing |
author_sort | Cao, Yan |
collection | PubMed |
description | INTRODUCTION: The association of mannose-binding lectin gene (MBL2) polymorphisms with tuberculosis susceptibility was inconclusive. In this study, a meta-analysis of 22 case-control studies was carried out to assess the effect of MBL2 polymorphisms on tuberculosis risk. MATERIAL AND METHODS: A search was performed in Embase, PubMed and Web of Science up to Sep 30, 2015. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the association. Statistical analyses were performed using STATA 12.0 software. RESULTS: rs1800451 was associated with a decreased tuberculosis risk in the allele model (C vs. A: OR = 0.93, 95% CI: 0.86–1.00, p = 0.050). In analyses stratified by ethnicity, rs7096206 (C/G: OR = 1.31, 95% CI: 1.10–1.57, p = 0.003; GG vs. GC + CC: OR = 0.69, 95% CI: 0.56–0.85, p < 0.001) and A/O (O/A: OR = 1.34, 95% CI: 1.10–1.64, p = 0.004) were associated with tuberculosis risk in Asians, A/O (AA vs. AO + OO: OR = 0.71, 95% CI: 0.51–0.99, p = 0.041) and rs1800451 (AC vs. AA + CC: OR = 2.70, 95% CI: 1.27–5.74, p = 0.010) were associated with tuberculosis risk in Americans, and rs1800451 (C/A: OR = 0.92, 95% CI: 0.86–0.99, p = 0.035) was associated with tuberculosis risk in Africans. Additionally, rs1800450 (B/A: OR = 0.42, 95% CI: 0.25–0.72, p = 0.001) was associated with tuberculosis risk in Europeans. CONCLUSIONS: The MBL2 rs1800451 polymorphism is associated with decreased TB risk in the general population, and A/O, rs7096206, rs1800450 and rs1800451 are likely to be associated with the risk for some specific ethnic groups. |
format | Online Article Text |
id | pubmed-6209707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-62097072018-11-02 Genetic polymorphisms of MBL2 and tuberculosis susceptibility: a meta-analysis of 22 case-control studies Cao, Yan Wang, Xinjing Cao, Zhihong Wu, Chunyan Wu, Dongmei Cheng, Xiaoxing Arch Med Sci Systematic review/Meta-analysis INTRODUCTION: The association of mannose-binding lectin gene (MBL2) polymorphisms with tuberculosis susceptibility was inconclusive. In this study, a meta-analysis of 22 case-control studies was carried out to assess the effect of MBL2 polymorphisms on tuberculosis risk. MATERIAL AND METHODS: A search was performed in Embase, PubMed and Web of Science up to Sep 30, 2015. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the association. Statistical analyses were performed using STATA 12.0 software. RESULTS: rs1800451 was associated with a decreased tuberculosis risk in the allele model (C vs. A: OR = 0.93, 95% CI: 0.86–1.00, p = 0.050). In analyses stratified by ethnicity, rs7096206 (C/G: OR = 1.31, 95% CI: 1.10–1.57, p = 0.003; GG vs. GC + CC: OR = 0.69, 95% CI: 0.56–0.85, p < 0.001) and A/O (O/A: OR = 1.34, 95% CI: 1.10–1.64, p = 0.004) were associated with tuberculosis risk in Asians, A/O (AA vs. AO + OO: OR = 0.71, 95% CI: 0.51–0.99, p = 0.041) and rs1800451 (AC vs. AA + CC: OR = 2.70, 95% CI: 1.27–5.74, p = 0.010) were associated with tuberculosis risk in Americans, and rs1800451 (C/A: OR = 0.92, 95% CI: 0.86–0.99, p = 0.035) was associated with tuberculosis risk in Africans. Additionally, rs1800450 (B/A: OR = 0.42, 95% CI: 0.25–0.72, p = 0.001) was associated with tuberculosis risk in Europeans. CONCLUSIONS: The MBL2 rs1800451 polymorphism is associated with decreased TB risk in the general population, and A/O, rs7096206, rs1800450 and rs1800451 are likely to be associated with the risk for some specific ethnic groups. Termedia Publishing House 2017-01-20 2018-10 /pmc/articles/PMC6209707/ /pubmed/30393476 http://dx.doi.org/10.5114/aoms.2017.65319 Text en Copyright: © 2017 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Systematic review/Meta-analysis Cao, Yan Wang, Xinjing Cao, Zhihong Wu, Chunyan Wu, Dongmei Cheng, Xiaoxing Genetic polymorphisms of MBL2 and tuberculosis susceptibility: a meta-analysis of 22 case-control studies |
title | Genetic polymorphisms of MBL2 and tuberculosis susceptibility: a meta-analysis of 22 case-control studies |
title_full | Genetic polymorphisms of MBL2 and tuberculosis susceptibility: a meta-analysis of 22 case-control studies |
title_fullStr | Genetic polymorphisms of MBL2 and tuberculosis susceptibility: a meta-analysis of 22 case-control studies |
title_full_unstemmed | Genetic polymorphisms of MBL2 and tuberculosis susceptibility: a meta-analysis of 22 case-control studies |
title_short | Genetic polymorphisms of MBL2 and tuberculosis susceptibility: a meta-analysis of 22 case-control studies |
title_sort | genetic polymorphisms of mbl2 and tuberculosis susceptibility: a meta-analysis of 22 case-control studies |
topic | Systematic review/Meta-analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209707/ https://www.ncbi.nlm.nih.gov/pubmed/30393476 http://dx.doi.org/10.5114/aoms.2017.65319 |
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