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From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly

BACKGROUND: Elderly patients are under‐represented in studies of pure ground‐glass opacity (pGGO) nodules; thus, this study analyzed the growth pattern and clinical outcomes of pGGO nodules in the elderly in order to help make treatment decisions. METHODS: We retrospectively reviewed patients aged o...

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Autores principales: Nie, Xin, Li, Lin, Huang, Juan, Zhang, Ping, Shi, Hong, Cheng, Gang, Zhang, Yong‐Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209797/
https://www.ncbi.nlm.nih.gov/pubmed/30144287
http://dx.doi.org/10.1111/1759-7714.12829
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author Nie, Xin
Li, Lin
Huang, Juan
Zhang, Ping
Shi, Hong
Cheng, Gang
Zhang, Yong‐Qiang
author_facet Nie, Xin
Li, Lin
Huang, Juan
Zhang, Ping
Shi, Hong
Cheng, Gang
Zhang, Yong‐Qiang
author_sort Nie, Xin
collection PubMed
description BACKGROUND: Elderly patients are under‐represented in studies of pure ground‐glass opacity (pGGO) nodules; thus, this study analyzed the growth pattern and clinical outcomes of pGGO nodules in the elderly in order to help make treatment decisions. METHODS: We retrospectively reviewed patients aged over 60 years with screening‐detected and pathologically confirmed growing focal pGGO nodules. RESULTS: During the study period, 858 subjects had undergone at least three low‐dose computed tomography scans in our center. Twenty patients were treated for growing focal pGGO nodules. The median age at detection was 66 years (range: 60–80). The median time to an increase of at least 2 mm was 348 days (range: 98–1527) and to develop a solid portion, 1141 days (range: 480–3010). Seven patients had surgery for increased nodule size, four had surgery immediately after the solid portion appeared, and nine were treated after a median follow‐up of 1153 days (range: 240–2342) since the solid portion developed. The median size of the solid component was 8 mm (2–13) before surgery. No recurrence was observed after a median follow‐up of 41 months. Pathology revealed adenocarcinoma in situ in five patients, and minimally invasive or invasive adenocarcinoma in the remainder. The appearance of a solid portion was significantly associated with invasive adenocarcinoma compared to increased size alone (100% vs. 44.4%; P = 0.005). CONCLUSIONS: pGGO nodules had an indolent growth pattern and good prognosis in our patient sample, even after the appearance of a solid portion. Therefore, minimally invasive surgery after the development of a solid component may be an option for the elderly.
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spelling pubmed-62097972018-11-16 From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly Nie, Xin Li, Lin Huang, Juan Zhang, Ping Shi, Hong Cheng, Gang Zhang, Yong‐Qiang Thorac Cancer Original Articles BACKGROUND: Elderly patients are under‐represented in studies of pure ground‐glass opacity (pGGO) nodules; thus, this study analyzed the growth pattern and clinical outcomes of pGGO nodules in the elderly in order to help make treatment decisions. METHODS: We retrospectively reviewed patients aged over 60 years with screening‐detected and pathologically confirmed growing focal pGGO nodules. RESULTS: During the study period, 858 subjects had undergone at least three low‐dose computed tomography scans in our center. Twenty patients were treated for growing focal pGGO nodules. The median age at detection was 66 years (range: 60–80). The median time to an increase of at least 2 mm was 348 days (range: 98–1527) and to develop a solid portion, 1141 days (range: 480–3010). Seven patients had surgery for increased nodule size, four had surgery immediately after the solid portion appeared, and nine were treated after a median follow‐up of 1153 days (range: 240–2342) since the solid portion developed. The median size of the solid component was 8 mm (2–13) before surgery. No recurrence was observed after a median follow‐up of 41 months. Pathology revealed adenocarcinoma in situ in five patients, and minimally invasive or invasive adenocarcinoma in the remainder. The appearance of a solid portion was significantly associated with invasive adenocarcinoma compared to increased size alone (100% vs. 44.4%; P = 0.005). CONCLUSIONS: pGGO nodules had an indolent growth pattern and good prognosis in our patient sample, even after the appearance of a solid portion. Therefore, minimally invasive surgery after the development of a solid component may be an option for the elderly. John Wiley & Sons Australia, Ltd 2018-08-24 2018-11 /pmc/articles/PMC6209797/ /pubmed/30144287 http://dx.doi.org/10.1111/1759-7714.12829 Text en © 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Nie, Xin
Li, Lin
Huang, Juan
Zhang, Ping
Shi, Hong
Cheng, Gang
Zhang, Yong‐Qiang
From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly
title From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly
title_full From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly
title_fullStr From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly
title_full_unstemmed From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly
title_short From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly
title_sort from focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: a growth pattern analysis in the elderly
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209797/
https://www.ncbi.nlm.nih.gov/pubmed/30144287
http://dx.doi.org/10.1111/1759-7714.12829
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