Cargando…
From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly
BACKGROUND: Elderly patients are under‐represented in studies of pure ground‐glass opacity (pGGO) nodules; thus, this study analyzed the growth pattern and clinical outcomes of pGGO nodules in the elderly in order to help make treatment decisions. METHODS: We retrospectively reviewed patients aged o...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209797/ https://www.ncbi.nlm.nih.gov/pubmed/30144287 http://dx.doi.org/10.1111/1759-7714.12829 |
_version_ | 1783366972028747776 |
---|---|
author | Nie, Xin Li, Lin Huang, Juan Zhang, Ping Shi, Hong Cheng, Gang Zhang, Yong‐Qiang |
author_facet | Nie, Xin Li, Lin Huang, Juan Zhang, Ping Shi, Hong Cheng, Gang Zhang, Yong‐Qiang |
author_sort | Nie, Xin |
collection | PubMed |
description | BACKGROUND: Elderly patients are under‐represented in studies of pure ground‐glass opacity (pGGO) nodules; thus, this study analyzed the growth pattern and clinical outcomes of pGGO nodules in the elderly in order to help make treatment decisions. METHODS: We retrospectively reviewed patients aged over 60 years with screening‐detected and pathologically confirmed growing focal pGGO nodules. RESULTS: During the study period, 858 subjects had undergone at least three low‐dose computed tomography scans in our center. Twenty patients were treated for growing focal pGGO nodules. The median age at detection was 66 years (range: 60–80). The median time to an increase of at least 2 mm was 348 days (range: 98–1527) and to develop a solid portion, 1141 days (range: 480–3010). Seven patients had surgery for increased nodule size, four had surgery immediately after the solid portion appeared, and nine were treated after a median follow‐up of 1153 days (range: 240–2342) since the solid portion developed. The median size of the solid component was 8 mm (2–13) before surgery. No recurrence was observed after a median follow‐up of 41 months. Pathology revealed adenocarcinoma in situ in five patients, and minimally invasive or invasive adenocarcinoma in the remainder. The appearance of a solid portion was significantly associated with invasive adenocarcinoma compared to increased size alone (100% vs. 44.4%; P = 0.005). CONCLUSIONS: pGGO nodules had an indolent growth pattern and good prognosis in our patient sample, even after the appearance of a solid portion. Therefore, minimally invasive surgery after the development of a solid component may be an option for the elderly. |
format | Online Article Text |
id | pubmed-6209797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-62097972018-11-16 From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly Nie, Xin Li, Lin Huang, Juan Zhang, Ping Shi, Hong Cheng, Gang Zhang, Yong‐Qiang Thorac Cancer Original Articles BACKGROUND: Elderly patients are under‐represented in studies of pure ground‐glass opacity (pGGO) nodules; thus, this study analyzed the growth pattern and clinical outcomes of pGGO nodules in the elderly in order to help make treatment decisions. METHODS: We retrospectively reviewed patients aged over 60 years with screening‐detected and pathologically confirmed growing focal pGGO nodules. RESULTS: During the study period, 858 subjects had undergone at least three low‐dose computed tomography scans in our center. Twenty patients were treated for growing focal pGGO nodules. The median age at detection was 66 years (range: 60–80). The median time to an increase of at least 2 mm was 348 days (range: 98–1527) and to develop a solid portion, 1141 days (range: 480–3010). Seven patients had surgery for increased nodule size, four had surgery immediately after the solid portion appeared, and nine were treated after a median follow‐up of 1153 days (range: 240–2342) since the solid portion developed. The median size of the solid component was 8 mm (2–13) before surgery. No recurrence was observed after a median follow‐up of 41 months. Pathology revealed adenocarcinoma in situ in five patients, and minimally invasive or invasive adenocarcinoma in the remainder. The appearance of a solid portion was significantly associated with invasive adenocarcinoma compared to increased size alone (100% vs. 44.4%; P = 0.005). CONCLUSIONS: pGGO nodules had an indolent growth pattern and good prognosis in our patient sample, even after the appearance of a solid portion. Therefore, minimally invasive surgery after the development of a solid component may be an option for the elderly. John Wiley & Sons Australia, Ltd 2018-08-24 2018-11 /pmc/articles/PMC6209797/ /pubmed/30144287 http://dx.doi.org/10.1111/1759-7714.12829 Text en © 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Nie, Xin Li, Lin Huang, Juan Zhang, Ping Shi, Hong Cheng, Gang Zhang, Yong‐Qiang From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly |
title | From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly |
title_full | From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly |
title_fullStr | From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly |
title_full_unstemmed | From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly |
title_short | From focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: A growth pattern analysis in the elderly |
title_sort | from focal pulmonary pure ground‐glass opacity nodule detected by low‐dose computed tomography into invasive lung adenocarcinoma: a growth pattern analysis in the elderly |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209797/ https://www.ncbi.nlm.nih.gov/pubmed/30144287 http://dx.doi.org/10.1111/1759-7714.12829 |
work_keys_str_mv | AT niexin fromfocalpulmonarypuregroundglassopacitynoduledetectedbylowdosecomputedtomographyintoinvasivelungadenocarcinomaagrowthpatternanalysisintheelderly AT lilin fromfocalpulmonarypuregroundglassopacitynoduledetectedbylowdosecomputedtomographyintoinvasivelungadenocarcinomaagrowthpatternanalysisintheelderly AT huangjuan fromfocalpulmonarypuregroundglassopacitynoduledetectedbylowdosecomputedtomographyintoinvasivelungadenocarcinomaagrowthpatternanalysisintheelderly AT zhangping fromfocalpulmonarypuregroundglassopacitynoduledetectedbylowdosecomputedtomographyintoinvasivelungadenocarcinomaagrowthpatternanalysisintheelderly AT shihong fromfocalpulmonarypuregroundglassopacitynoduledetectedbylowdosecomputedtomographyintoinvasivelungadenocarcinomaagrowthpatternanalysisintheelderly AT chenggang fromfocalpulmonarypuregroundglassopacitynoduledetectedbylowdosecomputedtomographyintoinvasivelungadenocarcinomaagrowthpatternanalysisintheelderly AT zhangyongqiang fromfocalpulmonarypuregroundglassopacitynoduledetectedbylowdosecomputedtomographyintoinvasivelungadenocarcinomaagrowthpatternanalysisintheelderly |