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Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma

[Image: see text] Introduction: Sorafenib (SFB) is an FDA-approved chemotherapeutic agent with a high partition coefficient (log P = 4.34) for monotherapy of hepatocellular carcinoma (HCC). The oral bioavailability is low and variable, so it was aimed to study the application of the polymeric nanoas...

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Detalles Bibliográficos
Autores principales:	Monajati, Maryam, Tavakoli, Shirin, Abolmaali, Samira Sadat, Yousefi, Gholamhossein, Tamaddon, AliMohammad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Tabriz University of Medical Sciences 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209830/ https://www.ncbi.nlm.nih.gov/pubmed/30397579 http://dx.doi.org/10.15171/bi.2018.27

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