Combined Effect of Bortezomib and Menadione Sodium Bisulfite on Proteasomes of Tumor Cells: The Dramatic Decrease of Bortezomib Toxicity in a Preclinical Trial

Tumor growth is associated with elevated proteasome expression and activity. This makes proteasomes a promising target for antitumor drugs. Current antitumor drugs such as bortezomib that inhibit proteasome activity have significant side effects. The purpose of the present study was to develop effec...

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Detalles Bibliográficos
Autores principales: Astakhova, Tatiana M., Morozov, Alexey V., Erokhov, Pavel A., Mikhailovskaya, Maria I., Akopov, Sergey B., Chupikova, Natalia I., Safarov, Ruslan R., Sharova, Natalia P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209890/
https://www.ncbi.nlm.nih.gov/pubmed/30257462
http://dx.doi.org/10.3390/cancers10100351

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