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FOXA1 levels are decreased in pleural breast cancer metastases after adjuvant endocrine therapy, and this is associated with poor outcome
Estrogen receptor‐alpha (ERα)‐positive breast cancer is often treated with antihormonal regimens. However, resistance to treatment is common, leading to metastatic disease. ERα activity requires the functional involvement of pioneer factors FOXA1 and GATA3, which enable ERα–chromatin binding and are...
Autores principales: | Schrijver, Willemijne, Schuurman, Karianne, van Rossum, Annelot, Droog, Marjolein, Jeronimo, Carmen, Salta, Sofia, Henrique, Rui, Wesseling, Jelle, Moelans, Cathy, Linn, Sabine C., van den Heuvel, Michel, van Diest, Paul, Zwart, Wilbert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210032/ https://www.ncbi.nlm.nih.gov/pubmed/29972720 http://dx.doi.org/10.1002/1878-0261.12353 |
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