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Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors

[Image: see text] Fatty acid amide hydrolase (FAAH) is responsible for regulating concentrations of the endocannabinoid arachidonoyl ethanolamide. Multiple FAAH inhibitors have been developed for clinical trials and have failed to demonstrate efficacy at treating pain, despite promising preclinical...

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Detalles Bibliográficos
Autores principales: Kodani, Sean D., Wan, Debin, Wagner, Karen M., Hwang, Sung Hee, Morisseau, Christophe, Hammock, Bruce D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210075/
https://www.ncbi.nlm.nih.gov/pubmed/30411058
http://dx.doi.org/10.1021/acsomega.8b01625