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Hysterectomies Are Associated with an Increased Risk of Depression: A Population-Based Cohort Study

Using the National Health Insurance Research Database of Taiwan, we investigated whether undergoing a hysterectomy increases the risk of depression. A total of 7872 patients aged 30–49 years who underwent a hysterectomy from 2000 to 2013 were enrolled as the hysterectomy group. The comparison group...

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Autores principales: Harnod, Tomor, Chen, Weishan, Wang, Jen-Hung, Lin, Shinn-Zong, Ding, Dah-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210125/
https://www.ncbi.nlm.nih.gov/pubmed/30340333
http://dx.doi.org/10.3390/jcm7100366
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author Harnod, Tomor
Chen, Weishan
Wang, Jen-Hung
Lin, Shinn-Zong
Ding, Dah-Ching
author_facet Harnod, Tomor
Chen, Weishan
Wang, Jen-Hung
Lin, Shinn-Zong
Ding, Dah-Ching
author_sort Harnod, Tomor
collection PubMed
description Using the National Health Insurance Research Database of Taiwan, we investigated whether undergoing a hysterectomy increases the risk of depression. A total of 7872 patients aged 30–49 years who underwent a hysterectomy from 2000 to 2013 were enrolled as the hysterectomy group. The comparison group was randomly selected from women who had never undergone a hysterectomy and was four times the size of the hysterectomy group. We calculated adjusted hazard ratios and 95% confidence intervals (CIs) for depression [The International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 296.2, 296.3, 300.4, 311] in these cohorts after adjusting for age, comorbidities, oophorectomy, and hormone therapy. The overall incidence of depression was 1.02 and 0.66 per 100 person-years in the hysterectomy and comparison cohorts, respectively, yielding an adjusted hazard ratio of 1.35 (95% CI = 1.22–1.50) for depression risk. When we stratified patients by age, comorbidities, oophorectomy, and hormone use, hysterectomy increased the risk of depression. Hysterectomy, oophorectomy, and post-surgery hormone use were associated with an increased risk of depression when they occurred alone, but conferred a greater risk if they were considered jointly. Hysterectomy would be a predisposing factor for increased risk of subsequent depression. Our findings provide vital information for patients, clinicians, and the government for improving the treatment strategy in the future.
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spelling pubmed-62101252018-11-02 Hysterectomies Are Associated with an Increased Risk of Depression: A Population-Based Cohort Study Harnod, Tomor Chen, Weishan Wang, Jen-Hung Lin, Shinn-Zong Ding, Dah-Ching J Clin Med Article Using the National Health Insurance Research Database of Taiwan, we investigated whether undergoing a hysterectomy increases the risk of depression. A total of 7872 patients aged 30–49 years who underwent a hysterectomy from 2000 to 2013 were enrolled as the hysterectomy group. The comparison group was randomly selected from women who had never undergone a hysterectomy and was four times the size of the hysterectomy group. We calculated adjusted hazard ratios and 95% confidence intervals (CIs) for depression [The International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 296.2, 296.3, 300.4, 311] in these cohorts after adjusting for age, comorbidities, oophorectomy, and hormone therapy. The overall incidence of depression was 1.02 and 0.66 per 100 person-years in the hysterectomy and comparison cohorts, respectively, yielding an adjusted hazard ratio of 1.35 (95% CI = 1.22–1.50) for depression risk. When we stratified patients by age, comorbidities, oophorectomy, and hormone use, hysterectomy increased the risk of depression. Hysterectomy, oophorectomy, and post-surgery hormone use were associated with an increased risk of depression when they occurred alone, but conferred a greater risk if they were considered jointly. Hysterectomy would be a predisposing factor for increased risk of subsequent depression. Our findings provide vital information for patients, clinicians, and the government for improving the treatment strategy in the future. MDPI 2018-10-18 /pmc/articles/PMC6210125/ /pubmed/30340333 http://dx.doi.org/10.3390/jcm7100366 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Harnod, Tomor
Chen, Weishan
Wang, Jen-Hung
Lin, Shinn-Zong
Ding, Dah-Ching
Hysterectomies Are Associated with an Increased Risk of Depression: A Population-Based Cohort Study
title Hysterectomies Are Associated with an Increased Risk of Depression: A Population-Based Cohort Study
title_full Hysterectomies Are Associated with an Increased Risk of Depression: A Population-Based Cohort Study
title_fullStr Hysterectomies Are Associated with an Increased Risk of Depression: A Population-Based Cohort Study
title_full_unstemmed Hysterectomies Are Associated with an Increased Risk of Depression: A Population-Based Cohort Study
title_short Hysterectomies Are Associated with an Increased Risk of Depression: A Population-Based Cohort Study
title_sort hysterectomies are associated with an increased risk of depression: a population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210125/
https://www.ncbi.nlm.nih.gov/pubmed/30340333
http://dx.doi.org/10.3390/jcm7100366
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