Cargando…

Aquaporins and Their Regulation after Spinal Cord Injury

After injury to the spinal cord, edema contributes to the underlying detrimental pathophysiological outcomes that lead to worsening of function. Several related membrane proteins called aquaporins (AQPs) regulate water movement in fluid transporting tissues including the spinal cord. Within the cord...

Descripción completa

Detalles Bibliográficos
Autores principales: Halsey, Andrea M., Conner, Alex C., Bill, Roslyn M., Logan, Ann, Ahmed, Zubair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210264/
https://www.ncbi.nlm.nih.gov/pubmed/30340399
http://dx.doi.org/10.3390/cells7100174
_version_ 1783367073248837632
author Halsey, Andrea M.
Conner, Alex C.
Bill, Roslyn M.
Logan, Ann
Ahmed, Zubair
author_facet Halsey, Andrea M.
Conner, Alex C.
Bill, Roslyn M.
Logan, Ann
Ahmed, Zubair
author_sort Halsey, Andrea M.
collection PubMed
description After injury to the spinal cord, edema contributes to the underlying detrimental pathophysiological outcomes that lead to worsening of function. Several related membrane proteins called aquaporins (AQPs) regulate water movement in fluid transporting tissues including the spinal cord. Within the cord, AQP1, 4 and 9 contribute to spinal cord injury (SCI)-induced edema. AQP1, 4 and 9 are expressed in a variety of cells including astrocytes, neurons, ependymal cells, and endothelial cells. This review discusses some of the recent findings of the involvement of AQP in SCI and highlights the need for further study of these proteins to develop effective therapies to counteract the negative effects of SCI-induced edema.
format Online
Article
Text
id pubmed-6210264
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62102642018-11-02 Aquaporins and Their Regulation after Spinal Cord Injury Halsey, Andrea M. Conner, Alex C. Bill, Roslyn M. Logan, Ann Ahmed, Zubair Cells Review After injury to the spinal cord, edema contributes to the underlying detrimental pathophysiological outcomes that lead to worsening of function. Several related membrane proteins called aquaporins (AQPs) regulate water movement in fluid transporting tissues including the spinal cord. Within the cord, AQP1, 4 and 9 contribute to spinal cord injury (SCI)-induced edema. AQP1, 4 and 9 are expressed in a variety of cells including astrocytes, neurons, ependymal cells, and endothelial cells. This review discusses some of the recent findings of the involvement of AQP in SCI and highlights the need for further study of these proteins to develop effective therapies to counteract the negative effects of SCI-induced edema. MDPI 2018-10-18 /pmc/articles/PMC6210264/ /pubmed/30340399 http://dx.doi.org/10.3390/cells7100174 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Halsey, Andrea M.
Conner, Alex C.
Bill, Roslyn M.
Logan, Ann
Ahmed, Zubair
Aquaporins and Their Regulation after Spinal Cord Injury
title Aquaporins and Their Regulation after Spinal Cord Injury
title_full Aquaporins and Their Regulation after Spinal Cord Injury
title_fullStr Aquaporins and Their Regulation after Spinal Cord Injury
title_full_unstemmed Aquaporins and Their Regulation after Spinal Cord Injury
title_short Aquaporins and Their Regulation after Spinal Cord Injury
title_sort aquaporins and their regulation after spinal cord injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210264/
https://www.ncbi.nlm.nih.gov/pubmed/30340399
http://dx.doi.org/10.3390/cells7100174
work_keys_str_mv AT halseyandream aquaporinsandtheirregulationafterspinalcordinjury
AT conneralexc aquaporinsandtheirregulationafterspinalcordinjury
AT billroslynm aquaporinsandtheirregulationafterspinalcordinjury
AT loganann aquaporinsandtheirregulationafterspinalcordinjury
AT ahmedzubair aquaporinsandtheirregulationafterspinalcordinjury