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Aquaporins and Their Regulation after Spinal Cord Injury
After injury to the spinal cord, edema contributes to the underlying detrimental pathophysiological outcomes that lead to worsening of function. Several related membrane proteins called aquaporins (AQPs) regulate water movement in fluid transporting tissues including the spinal cord. Within the cord...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210264/ https://www.ncbi.nlm.nih.gov/pubmed/30340399 http://dx.doi.org/10.3390/cells7100174 |
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author | Halsey, Andrea M. Conner, Alex C. Bill, Roslyn M. Logan, Ann Ahmed, Zubair |
author_facet | Halsey, Andrea M. Conner, Alex C. Bill, Roslyn M. Logan, Ann Ahmed, Zubair |
author_sort | Halsey, Andrea M. |
collection | PubMed |
description | After injury to the spinal cord, edema contributes to the underlying detrimental pathophysiological outcomes that lead to worsening of function. Several related membrane proteins called aquaporins (AQPs) regulate water movement in fluid transporting tissues including the spinal cord. Within the cord, AQP1, 4 and 9 contribute to spinal cord injury (SCI)-induced edema. AQP1, 4 and 9 are expressed in a variety of cells including astrocytes, neurons, ependymal cells, and endothelial cells. This review discusses some of the recent findings of the involvement of AQP in SCI and highlights the need for further study of these proteins to develop effective therapies to counteract the negative effects of SCI-induced edema. |
format | Online Article Text |
id | pubmed-6210264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62102642018-11-02 Aquaporins and Their Regulation after Spinal Cord Injury Halsey, Andrea M. Conner, Alex C. Bill, Roslyn M. Logan, Ann Ahmed, Zubair Cells Review After injury to the spinal cord, edema contributes to the underlying detrimental pathophysiological outcomes that lead to worsening of function. Several related membrane proteins called aquaporins (AQPs) regulate water movement in fluid transporting tissues including the spinal cord. Within the cord, AQP1, 4 and 9 contribute to spinal cord injury (SCI)-induced edema. AQP1, 4 and 9 are expressed in a variety of cells including astrocytes, neurons, ependymal cells, and endothelial cells. This review discusses some of the recent findings of the involvement of AQP in SCI and highlights the need for further study of these proteins to develop effective therapies to counteract the negative effects of SCI-induced edema. MDPI 2018-10-18 /pmc/articles/PMC6210264/ /pubmed/30340399 http://dx.doi.org/10.3390/cells7100174 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Halsey, Andrea M. Conner, Alex C. Bill, Roslyn M. Logan, Ann Ahmed, Zubair Aquaporins and Their Regulation after Spinal Cord Injury |
title | Aquaporins and Their Regulation after Spinal Cord Injury |
title_full | Aquaporins and Their Regulation after Spinal Cord Injury |
title_fullStr | Aquaporins and Their Regulation after Spinal Cord Injury |
title_full_unstemmed | Aquaporins and Their Regulation after Spinal Cord Injury |
title_short | Aquaporins and Their Regulation after Spinal Cord Injury |
title_sort | aquaporins and their regulation after spinal cord injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210264/ https://www.ncbi.nlm.nih.gov/pubmed/30340399 http://dx.doi.org/10.3390/cells7100174 |
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