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The C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients
The C-reactive protein (CRP)/albumin ratio has recently emerged as a marker for poor prognosis or mortality across various patient groups. This study aimed to identify the association between CRP/albumin ratio and 28-day mortality and predict the accuracy of CRP/albumin ratio for 28-day mortality in...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210319/ https://www.ncbi.nlm.nih.gov/pubmed/30297655 http://dx.doi.org/10.3390/jcm7100333 |
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author | Park, Ji Eun Chung, Kyung Soo Song, Joo Han Kim, Song Yee Kim, Eun Young Jung, Ji Ye Kang, Young Ae Park, Moo Suk Kim, Young Sam Chang, Joon Leem, Ah Young |
author_facet | Park, Ji Eun Chung, Kyung Soo Song, Joo Han Kim, Song Yee Kim, Eun Young Jung, Ji Ye Kang, Young Ae Park, Moo Suk Kim, Young Sam Chang, Joon Leem, Ah Young |
author_sort | Park, Ji Eun |
collection | PubMed |
description | The C-reactive protein (CRP)/albumin ratio has recently emerged as a marker for poor prognosis or mortality across various patient groups. This study aimed to identify the association between CRP/albumin ratio and 28-day mortality and predict the accuracy of CRP/albumin ratio for 28-day mortality in medical intensive care unit (ICU) patients. This was a retrospective cohort study of 875 patients. We evaluated the prognostic value of CRP/albumin ratio to predict mortality at 28 days after ICU admission, using Cox proportional hazard model and Kaplan-Meier survival analysis. The 28-day mortality was 28.0%. In the univariate analysis, the Acute Physiology and Chronic Health Evaluation II (APACHE II) score (p < 0.001), CRP level (p = 0.045), albumin level (p < 0.001), and CRP/albumin ratio (p = 0.032) were related to 28-day mortality. The area under the receiver operating characteristic (ROC) curve (the area under the ROC curves (AUC)) of CRP/albumin ratio was higher than that of CRP for mortality (0.594 vs. 0.567, p < 0.001). The cut-off point for CRP/albumin ratio for mortality was 34.3. On Cox proportional-hazard regression analysis, APACHE II score (hazards ratio (HR) = 1.05, 95% confidence interval (CI) = 1.04–1.07, p < 0.001) and CRP/albumin ratio (HR = 1.68, 95% CI = 1.27–2.21, p < 0.001 for high CRP/albumin ratio) were independent predictors of 28-day mortality. Higher CRP/albumin ratio was associated with increased mortality in critically ill patients. |
format | Online Article Text |
id | pubmed-6210319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62103192018-11-02 The C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients Park, Ji Eun Chung, Kyung Soo Song, Joo Han Kim, Song Yee Kim, Eun Young Jung, Ji Ye Kang, Young Ae Park, Moo Suk Kim, Young Sam Chang, Joon Leem, Ah Young J Clin Med Article The C-reactive protein (CRP)/albumin ratio has recently emerged as a marker for poor prognosis or mortality across various patient groups. This study aimed to identify the association between CRP/albumin ratio and 28-day mortality and predict the accuracy of CRP/albumin ratio for 28-day mortality in medical intensive care unit (ICU) patients. This was a retrospective cohort study of 875 patients. We evaluated the prognostic value of CRP/albumin ratio to predict mortality at 28 days after ICU admission, using Cox proportional hazard model and Kaplan-Meier survival analysis. The 28-day mortality was 28.0%. In the univariate analysis, the Acute Physiology and Chronic Health Evaluation II (APACHE II) score (p < 0.001), CRP level (p = 0.045), albumin level (p < 0.001), and CRP/albumin ratio (p = 0.032) were related to 28-day mortality. The area under the receiver operating characteristic (ROC) curve (the area under the ROC curves (AUC)) of CRP/albumin ratio was higher than that of CRP for mortality (0.594 vs. 0.567, p < 0.001). The cut-off point for CRP/albumin ratio for mortality was 34.3. On Cox proportional-hazard regression analysis, APACHE II score (hazards ratio (HR) = 1.05, 95% confidence interval (CI) = 1.04–1.07, p < 0.001) and CRP/albumin ratio (HR = 1.68, 95% CI = 1.27–2.21, p < 0.001 for high CRP/albumin ratio) were independent predictors of 28-day mortality. Higher CRP/albumin ratio was associated with increased mortality in critically ill patients. MDPI 2018-10-08 /pmc/articles/PMC6210319/ /pubmed/30297655 http://dx.doi.org/10.3390/jcm7100333 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Park, Ji Eun Chung, Kyung Soo Song, Joo Han Kim, Song Yee Kim, Eun Young Jung, Ji Ye Kang, Young Ae Park, Moo Suk Kim, Young Sam Chang, Joon Leem, Ah Young The C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients |
title | The C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients |
title_full | The C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients |
title_fullStr | The C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients |
title_full_unstemmed | The C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients |
title_short | The C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients |
title_sort | c-reactive protein/albumin ratio as a predictor of mortality in critically ill patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210319/ https://www.ncbi.nlm.nih.gov/pubmed/30297655 http://dx.doi.org/10.3390/jcm7100333 |
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