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Emerging Picture of Deuterosome-Dependent Centriole Amplification in MCCs

Multiciliated cells (MCCs) have several hair-like structures called cilia, which are required to propel substances on their surface. A cilium is organized from a basal body which resembles a hollow microtubule structure called a centriole. In terminally differentiated MCCs, hundreds of new basal bod...

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Autores principales: Shahid, Umama, Singh, Priyanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210342/
https://www.ncbi.nlm.nih.gov/pubmed/30262752
http://dx.doi.org/10.3390/cells7100152
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author Shahid, Umama
Singh, Priyanka
author_facet Shahid, Umama
Singh, Priyanka
author_sort Shahid, Umama
collection PubMed
description Multiciliated cells (MCCs) have several hair-like structures called cilia, which are required to propel substances on their surface. A cilium is organized from a basal body which resembles a hollow microtubule structure called a centriole. In terminally differentiated MCCs, hundreds of new basal bodies/centrioles are formed via two parallel pathways: the centriole- and deuterosome-dependent pathways. The deuterosome-dependent pathway is also referred to as “de novo” because unlike the centriole-dependent pathway which requires pre-existing centrioles, in the de novo pathway multiple new centrioles are organized around non-microtubule structures called deuterosomes. In the last five years, some deuterosome-specific markers have been identified and concurrent advancements in the super-resolution techniques have significantly contributed to gaining insights about the major stages of centriole amplification during ciliogenesis. Altogether, a new picture is emerging which also challenges the previous notion that deuterosome pathway is de novo. This review is primarily focused on studies that have contributed towards the better understanding of deuterosome-dependent centriole amplification and presents a developing model about the major stages identified during this process.
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spelling pubmed-62103422018-11-02 Emerging Picture of Deuterosome-Dependent Centriole Amplification in MCCs Shahid, Umama Singh, Priyanka Cells Review Multiciliated cells (MCCs) have several hair-like structures called cilia, which are required to propel substances on their surface. A cilium is organized from a basal body which resembles a hollow microtubule structure called a centriole. In terminally differentiated MCCs, hundreds of new basal bodies/centrioles are formed via two parallel pathways: the centriole- and deuterosome-dependent pathways. The deuterosome-dependent pathway is also referred to as “de novo” because unlike the centriole-dependent pathway which requires pre-existing centrioles, in the de novo pathway multiple new centrioles are organized around non-microtubule structures called deuterosomes. In the last five years, some deuterosome-specific markers have been identified and concurrent advancements in the super-resolution techniques have significantly contributed to gaining insights about the major stages of centriole amplification during ciliogenesis. Altogether, a new picture is emerging which also challenges the previous notion that deuterosome pathway is de novo. This review is primarily focused on studies that have contributed towards the better understanding of deuterosome-dependent centriole amplification and presents a developing model about the major stages identified during this process. MDPI 2018-09-27 /pmc/articles/PMC6210342/ /pubmed/30262752 http://dx.doi.org/10.3390/cells7100152 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shahid, Umama
Singh, Priyanka
Emerging Picture of Deuterosome-Dependent Centriole Amplification in MCCs
title Emerging Picture of Deuterosome-Dependent Centriole Amplification in MCCs
title_full Emerging Picture of Deuterosome-Dependent Centriole Amplification in MCCs
title_fullStr Emerging Picture of Deuterosome-Dependent Centriole Amplification in MCCs
title_full_unstemmed Emerging Picture of Deuterosome-Dependent Centriole Amplification in MCCs
title_short Emerging Picture of Deuterosome-Dependent Centriole Amplification in MCCs
title_sort emerging picture of deuterosome-dependent centriole amplification in mccs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210342/
https://www.ncbi.nlm.nih.gov/pubmed/30262752
http://dx.doi.org/10.3390/cells7100152
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