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Optical Micro/Nanofiber-Based Localized Surface Plasmon Resonance Biosensors: Fiber Diameter Dependence
Integration of functional nanomaterials with optical micro/nanofibers (OMNFs) can bring about novel optical properties and provide a versatile platform for various sensing applications. OMNFs as the key element, however, have seldom been investigated. Here, we focus on the optimization of fiber diam...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210447/ https://www.ncbi.nlm.nih.gov/pubmed/30274387 http://dx.doi.org/10.3390/s18103295 |
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author | Li, Kaiwei Zhou, Wenchao Zeng, Shuwen |
author_facet | Li, Kaiwei Zhou, Wenchao Zeng, Shuwen |
author_sort | Li, Kaiwei |
collection | PubMed |
description | Integration of functional nanomaterials with optical micro/nanofibers (OMNFs) can bring about novel optical properties and provide a versatile platform for various sensing applications. OMNFs as the key element, however, have seldom been investigated. Here, we focus on the optimization of fiber diameter by taking micro/nanofiber-based localized surface plasmon resonance sensors as a model. We systematically study the dependence of fiber diameter on the sensing performance of such sensors. Both theoretical and experimental results show that, by reducing fiber diameter, the refractive index sensitivity can be significantly increased. Then, we demonstrate the biosensing capability of the optimized sensor for streptavidin detection and achieve a detection limit of 1 pg/mL. Furthermore, the proposed theoretical model is applicable to other nanomaterials and OMNF-based sensing schemes for performance optimization. |
format | Online Article Text |
id | pubmed-6210447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62104472018-11-02 Optical Micro/Nanofiber-Based Localized Surface Plasmon Resonance Biosensors: Fiber Diameter Dependence Li, Kaiwei Zhou, Wenchao Zeng, Shuwen Sensors (Basel) Article Integration of functional nanomaterials with optical micro/nanofibers (OMNFs) can bring about novel optical properties and provide a versatile platform for various sensing applications. OMNFs as the key element, however, have seldom been investigated. Here, we focus on the optimization of fiber diameter by taking micro/nanofiber-based localized surface plasmon resonance sensors as a model. We systematically study the dependence of fiber diameter on the sensing performance of such sensors. Both theoretical and experimental results show that, by reducing fiber diameter, the refractive index sensitivity can be significantly increased. Then, we demonstrate the biosensing capability of the optimized sensor for streptavidin detection and achieve a detection limit of 1 pg/mL. Furthermore, the proposed theoretical model is applicable to other nanomaterials and OMNF-based sensing schemes for performance optimization. MDPI 2018-09-30 /pmc/articles/PMC6210447/ /pubmed/30274387 http://dx.doi.org/10.3390/s18103295 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Kaiwei Zhou, Wenchao Zeng, Shuwen Optical Micro/Nanofiber-Based Localized Surface Plasmon Resonance Biosensors: Fiber Diameter Dependence |
title | Optical Micro/Nanofiber-Based Localized Surface Plasmon Resonance Biosensors: Fiber Diameter Dependence |
title_full | Optical Micro/Nanofiber-Based Localized Surface Plasmon Resonance Biosensors: Fiber Diameter Dependence |
title_fullStr | Optical Micro/Nanofiber-Based Localized Surface Plasmon Resonance Biosensors: Fiber Diameter Dependence |
title_full_unstemmed | Optical Micro/Nanofiber-Based Localized Surface Plasmon Resonance Biosensors: Fiber Diameter Dependence |
title_short | Optical Micro/Nanofiber-Based Localized Surface Plasmon Resonance Biosensors: Fiber Diameter Dependence |
title_sort | optical micro/nanofiber-based localized surface plasmon resonance biosensors: fiber diameter dependence |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210447/ https://www.ncbi.nlm.nih.gov/pubmed/30274387 http://dx.doi.org/10.3390/s18103295 |
work_keys_str_mv | AT likaiwei opticalmicronanofiberbasedlocalizedsurfaceplasmonresonancebiosensorsfiberdiameterdependence AT zhouwenchao opticalmicronanofiberbasedlocalizedsurfaceplasmonresonancebiosensorsfiberdiameterdependence AT zengshuwen opticalmicronanofiberbasedlocalizedsurfaceplasmonresonancebiosensorsfiberdiameterdependence |