Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy

Ovarian cancer, a rare but fatal disease, has been a challenging area in the field of gynecological cancer. Ovarian cancer is characterized by peritoneal metastasis, which is facilitated by a cross-talk between tumor cells and other cells in the tumor microenvironment (TME). In epithelial ovarian ca...

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Detalles Bibliográficos
Autores principales: Gupta, Vijayalaxmi, Yull, Fiona, Khabele, Dineo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210537/
https://www.ncbi.nlm.nih.gov/pubmed/30274280
http://dx.doi.org/10.3390/cancers10100366
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author Gupta, Vijayalaxmi
Yull, Fiona
Khabele, Dineo
author_facet Gupta, Vijayalaxmi
Yull, Fiona
Khabele, Dineo
author_sort Gupta, Vijayalaxmi
collection PubMed
description Ovarian cancer, a rare but fatal disease, has been a challenging area in the field of gynecological cancer. Ovarian cancer is characterized by peritoneal metastasis, which is facilitated by a cross-talk between tumor cells and other cells in the tumor microenvironment (TME). In epithelial ovarian cancer, tumor-associated macrophages (TAMs) constitute over 50% of cells in the peritoneal TME and malignant ascites, and are potential targets for therapy. Here, we review the bipolar nature of TAMs and the evolving strategies to target TAMs in ovarian cancer.
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spelling pubmed-62105372018-11-02 Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy Gupta, Vijayalaxmi Yull, Fiona Khabele, Dineo Cancers (Basel) Review Ovarian cancer, a rare but fatal disease, has been a challenging area in the field of gynecological cancer. Ovarian cancer is characterized by peritoneal metastasis, which is facilitated by a cross-talk between tumor cells and other cells in the tumor microenvironment (TME). In epithelial ovarian cancer, tumor-associated macrophages (TAMs) constitute over 50% of cells in the peritoneal TME and malignant ascites, and are potential targets for therapy. Here, we review the bipolar nature of TAMs and the evolving strategies to target TAMs in ovarian cancer. MDPI 2018-09-29 /pmc/articles/PMC6210537/ /pubmed/30274280 http://dx.doi.org/10.3390/cancers10100366 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gupta, Vijayalaxmi
Yull, Fiona
Khabele, Dineo
Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy
title Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy
title_full Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy
title_fullStr Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy
title_full_unstemmed Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy
title_short Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy
title_sort bipolar tumor-associated macrophages in ovarian cancer as targets for therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210537/
https://www.ncbi.nlm.nih.gov/pubmed/30274280
http://dx.doi.org/10.3390/cancers10100366
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AT khabeledineo bipolartumorassociatedmacrophagesinovariancancerastargetsfortherapy

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