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Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis

Neisseria meningitidis, an obligate pathogenic bacterium in humans, has acquired different defense mechanisms to detect and fight the oxidative stress generated by the host’s defense during infection. A notable example of such a mechanism is the PilB reducing system, which repairs oxidatively-damage...

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Autor principal: Boschi-Muller, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210582/
https://www.ncbi.nlm.nih.gov/pubmed/30275362
http://dx.doi.org/10.3390/antiox7100131
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author Boschi-Muller, Sandrine
author_facet Boschi-Muller, Sandrine
author_sort Boschi-Muller, Sandrine
collection PubMed
description Neisseria meningitidis, an obligate pathogenic bacterium in humans, has acquired different defense mechanisms to detect and fight the oxidative stress generated by the host’s defense during infection. A notable example of such a mechanism is the PilB reducing system, which repairs oxidatively-damaged methionine residues. This review will focus on the catalytic mechanism of the two methionine sulfoxide reductase (MSR) domains of PilB, which represent model enzymes for catalysis of the reduction of a sulfoxide function by thiols through sulfenic acid chemistry. The mechanism of recycling of these MSR domains by various “Trx-like” disulfide oxidoreductases will also be discussed.
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spelling pubmed-62105822018-11-05 Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis Boschi-Muller, Sandrine Antioxidants (Basel) Review Neisseria meningitidis, an obligate pathogenic bacterium in humans, has acquired different defense mechanisms to detect and fight the oxidative stress generated by the host’s defense during infection. A notable example of such a mechanism is the PilB reducing system, which repairs oxidatively-damaged methionine residues. This review will focus on the catalytic mechanism of the two methionine sulfoxide reductase (MSR) domains of PilB, which represent model enzymes for catalysis of the reduction of a sulfoxide function by thiols through sulfenic acid chemistry. The mechanism of recycling of these MSR domains by various “Trx-like” disulfide oxidoreductases will also be discussed. MDPI 2018-10-01 /pmc/articles/PMC6210582/ /pubmed/30275362 http://dx.doi.org/10.3390/antiox7100131 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Boschi-Muller, Sandrine
Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis
title Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis
title_full Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis
title_fullStr Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis
title_full_unstemmed Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis
title_short Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis
title_sort molecular mechanisms of the methionine sulfoxide reductase system from neisseria meningitidis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210582/
https://www.ncbi.nlm.nih.gov/pubmed/30275362
http://dx.doi.org/10.3390/antiox7100131
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