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Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis
Neisseria meningitidis, an obligate pathogenic bacterium in humans, has acquired different defense mechanisms to detect and fight the oxidative stress generated by the host’s defense during infection. A notable example of such a mechanism is the PilB reducing system, which repairs oxidatively-damage...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210582/ https://www.ncbi.nlm.nih.gov/pubmed/30275362 http://dx.doi.org/10.3390/antiox7100131 |
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author | Boschi-Muller, Sandrine |
author_facet | Boschi-Muller, Sandrine |
author_sort | Boschi-Muller, Sandrine |
collection | PubMed |
description | Neisseria meningitidis, an obligate pathogenic bacterium in humans, has acquired different defense mechanisms to detect and fight the oxidative stress generated by the host’s defense during infection. A notable example of such a mechanism is the PilB reducing system, which repairs oxidatively-damaged methionine residues. This review will focus on the catalytic mechanism of the two methionine sulfoxide reductase (MSR) domains of PilB, which represent model enzymes for catalysis of the reduction of a sulfoxide function by thiols through sulfenic acid chemistry. The mechanism of recycling of these MSR domains by various “Trx-like” disulfide oxidoreductases will also be discussed. |
format | Online Article Text |
id | pubmed-6210582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62105822018-11-05 Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis Boschi-Muller, Sandrine Antioxidants (Basel) Review Neisseria meningitidis, an obligate pathogenic bacterium in humans, has acquired different defense mechanisms to detect and fight the oxidative stress generated by the host’s defense during infection. A notable example of such a mechanism is the PilB reducing system, which repairs oxidatively-damaged methionine residues. This review will focus on the catalytic mechanism of the two methionine sulfoxide reductase (MSR) domains of PilB, which represent model enzymes for catalysis of the reduction of a sulfoxide function by thiols through sulfenic acid chemistry. The mechanism of recycling of these MSR domains by various “Trx-like” disulfide oxidoreductases will also be discussed. MDPI 2018-10-01 /pmc/articles/PMC6210582/ /pubmed/30275362 http://dx.doi.org/10.3390/antiox7100131 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Boschi-Muller, Sandrine Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis |
title | Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis |
title_full | Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis |
title_fullStr | Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis |
title_full_unstemmed | Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis |
title_short | Molecular Mechanisms of the Methionine Sulfoxide Reductase System from Neisseria meningitidis |
title_sort | molecular mechanisms of the methionine sulfoxide reductase system from neisseria meningitidis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210582/ https://www.ncbi.nlm.nih.gov/pubmed/30275362 http://dx.doi.org/10.3390/antiox7100131 |
work_keys_str_mv | AT boschimullersandrine molecularmechanismsofthemethioninesulfoxidereductasesystemfromneisseriameningitidis |