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Development of a Screening Method for Health Hazard Ranking and Scoring of Chemicals Using the Mahalanobis–Taguchi System

For efficient management of chemicals, it is necessary to preferentially select hazardous chemicals as being high-priority through a screening method. Over the past 20 years, chemical ranking and scoring (CRS) methods have been applied in many countries; however, these CRS methods have a few limitat...

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Autores principales: Huh, Da-An, Lim, Hong Lyuer, Sohn, Jong-Ryeul, Byeon, Sang-Hoon, Jung, Soonyoung, Lee, Woo-Kyun, Moon, Kyong Whan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210662/
https://www.ncbi.nlm.nih.gov/pubmed/30308988
http://dx.doi.org/10.3390/ijerph15102208
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author Huh, Da-An
Lim, Hong Lyuer
Sohn, Jong-Ryeul
Byeon, Sang-Hoon
Jung, Soonyoung
Lee, Woo-Kyun
Moon, Kyong Whan
author_facet Huh, Da-An
Lim, Hong Lyuer
Sohn, Jong-Ryeul
Byeon, Sang-Hoon
Jung, Soonyoung
Lee, Woo-Kyun
Moon, Kyong Whan
author_sort Huh, Da-An
collection PubMed
description For efficient management of chemicals, it is necessary to preferentially select hazardous chemicals as being high-priority through a screening method. Over the past 20 years, chemical ranking and scoring (CRS) methods have been applied in many countries; however, these CRS methods have a few limitations. Most of the existing methods only use some of the variables to calculate the hazard of chemicals or use the most conservative score without consideration of the correlation between chemical toxicities. This evaluation could underestimate or overestimate the real health hazard of the chemicals. To overcome the limitations of these methods, we developed a new CRS method using the Mahalanobis–Taguchi System (MTS). The MTS, which conducts multivariate analysis, produced chemical rankings that took into accounts the correlation between variables related to chemical health hazards. Also, the proportion of chemicals managed by the Korea Chemicals Control Act that were given a high rating appeared to be higher when the MTS was used, compared to the existing methods. These results indicated that the new method evaluated the health hazards of chemicals more accurately, and we expect that the MTS method could be applied to a greater range of chemicals than the existing CRS methods.
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spelling pubmed-62106622018-11-02 Development of a Screening Method for Health Hazard Ranking and Scoring of Chemicals Using the Mahalanobis–Taguchi System Huh, Da-An Lim, Hong Lyuer Sohn, Jong-Ryeul Byeon, Sang-Hoon Jung, Soonyoung Lee, Woo-Kyun Moon, Kyong Whan Int J Environ Res Public Health Article For efficient management of chemicals, it is necessary to preferentially select hazardous chemicals as being high-priority through a screening method. Over the past 20 years, chemical ranking and scoring (CRS) methods have been applied in many countries; however, these CRS methods have a few limitations. Most of the existing methods only use some of the variables to calculate the hazard of chemicals or use the most conservative score without consideration of the correlation between chemical toxicities. This evaluation could underestimate or overestimate the real health hazard of the chemicals. To overcome the limitations of these methods, we developed a new CRS method using the Mahalanobis–Taguchi System (MTS). The MTS, which conducts multivariate analysis, produced chemical rankings that took into accounts the correlation between variables related to chemical health hazards. Also, the proportion of chemicals managed by the Korea Chemicals Control Act that were given a high rating appeared to be higher when the MTS was used, compared to the existing methods. These results indicated that the new method evaluated the health hazards of chemicals more accurately, and we expect that the MTS method could be applied to a greater range of chemicals than the existing CRS methods. MDPI 2018-10-10 2018-10 /pmc/articles/PMC6210662/ /pubmed/30308988 http://dx.doi.org/10.3390/ijerph15102208 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huh, Da-An
Lim, Hong Lyuer
Sohn, Jong-Ryeul
Byeon, Sang-Hoon
Jung, Soonyoung
Lee, Woo-Kyun
Moon, Kyong Whan
Development of a Screening Method for Health Hazard Ranking and Scoring of Chemicals Using the Mahalanobis–Taguchi System
title Development of a Screening Method for Health Hazard Ranking and Scoring of Chemicals Using the Mahalanobis–Taguchi System
title_full Development of a Screening Method for Health Hazard Ranking and Scoring of Chemicals Using the Mahalanobis–Taguchi System
title_fullStr Development of a Screening Method for Health Hazard Ranking and Scoring of Chemicals Using the Mahalanobis–Taguchi System
title_full_unstemmed Development of a Screening Method for Health Hazard Ranking and Scoring of Chemicals Using the Mahalanobis–Taguchi System
title_short Development of a Screening Method for Health Hazard Ranking and Scoring of Chemicals Using the Mahalanobis–Taguchi System
title_sort development of a screening method for health hazard ranking and scoring of chemicals using the mahalanobis–taguchi system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210662/
https://www.ncbi.nlm.nih.gov/pubmed/30308988
http://dx.doi.org/10.3390/ijerph15102208
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