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Potential Diagnostic Properties of Chest Ultrasound in Thoracic Tuberculosis—A Systematic Review

Background: Chest ultrasound (CUS) has been shown to be a sensitive and specific imaging modality for pneumothorax, pneumonia, and pleural effusions. However, the role of chest ultrasound in the diagnosis of thoracic tuberculosis (TB) is uncertain. We performed a systematic search in the medical lit...

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Autores principales: Di Gennaro, Francesco, Pisani, Luigi, Veronese, Nicola, Pizzol, Damiano, Lippolis, Valeria, Saracino, Annalisa, Monno, Laura, Huson, Michaëla A.M., Copetti, Roberto, Putoto, Giovanni, Schultz, Marcus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210728/
https://www.ncbi.nlm.nih.gov/pubmed/30322009
http://dx.doi.org/10.3390/ijerph15102235
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author Di Gennaro, Francesco
Pisani, Luigi
Veronese, Nicola
Pizzol, Damiano
Lippolis, Valeria
Saracino, Annalisa
Monno, Laura
Huson, Michaëla A.M.
Copetti, Roberto
Putoto, Giovanni
Schultz, Marcus J.
author_facet Di Gennaro, Francesco
Pisani, Luigi
Veronese, Nicola
Pizzol, Damiano
Lippolis, Valeria
Saracino, Annalisa
Monno, Laura
Huson, Michaëla A.M.
Copetti, Roberto
Putoto, Giovanni
Schultz, Marcus J.
author_sort Di Gennaro, Francesco
collection PubMed
description Background: Chest ultrasound (CUS) has been shown to be a sensitive and specific imaging modality for pneumothorax, pneumonia, and pleural effusions. However, the role of chest ultrasound in the diagnosis of thoracic tuberculosis (TB) is uncertain. We performed a systematic search in the medical literature to better define the potential role and value of chest ultrasound in diagnosing thoracic tuberculosis. Aim: To describe existing literature with regard to the diagnostic value of chest ultrasound in thoracic tuberculosis. Methods: MEDLINE, EMBASE, and Scopus databases were searched for relevant articles. We included studies that used chest ultrasound for the diagnosis or management of any form of thoracic tuberculosis, including pulmonary, pleural, mediastinal, and military forms. Results: We identified five main fields of chest ultrasound application: (1) Detection, characterization, and quantification of TB; (2) detection of residual pleural thickening after evacuation; (3) chest ultrasound-guided needle biopsy; (4) identification of pathologic mediastinal lymph nodes in children; and (5) identification of parenchymal ultrasound patterns. Effusion was also detected, in early stages, with signs of organization in 24–100% of patients. A low to moderate (10–23%), false negative rate was reported for chest ultrasound-guided needle biopsy. CUS was able to identify mediastinal lymph nodes in as many as 67% of patients with negative chest radiography. Conclusions: Very few studies with important methodological limitations analyze the role of chest ultrasound in the diagnosis of TB. The scarce available data suggests potential targets of future diagnostic or feasibility trials, such as the detection of tuberculosis–related pleural effusion, residual pleural thickening, lymphadenopathy, TB parenchymal patterns, or the use of CUS in biopsy guidance.
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spelling pubmed-62107282018-11-02 Potential Diagnostic Properties of Chest Ultrasound in Thoracic Tuberculosis—A Systematic Review Di Gennaro, Francesco Pisani, Luigi Veronese, Nicola Pizzol, Damiano Lippolis, Valeria Saracino, Annalisa Monno, Laura Huson, Michaëla A.M. Copetti, Roberto Putoto, Giovanni Schultz, Marcus J. Int J Environ Res Public Health Review Background: Chest ultrasound (CUS) has been shown to be a sensitive and specific imaging modality for pneumothorax, pneumonia, and pleural effusions. However, the role of chest ultrasound in the diagnosis of thoracic tuberculosis (TB) is uncertain. We performed a systematic search in the medical literature to better define the potential role and value of chest ultrasound in diagnosing thoracic tuberculosis. Aim: To describe existing literature with regard to the diagnostic value of chest ultrasound in thoracic tuberculosis. Methods: MEDLINE, EMBASE, and Scopus databases were searched for relevant articles. We included studies that used chest ultrasound for the diagnosis or management of any form of thoracic tuberculosis, including pulmonary, pleural, mediastinal, and military forms. Results: We identified five main fields of chest ultrasound application: (1) Detection, characterization, and quantification of TB; (2) detection of residual pleural thickening after evacuation; (3) chest ultrasound-guided needle biopsy; (4) identification of pathologic mediastinal lymph nodes in children; and (5) identification of parenchymal ultrasound patterns. Effusion was also detected, in early stages, with signs of organization in 24–100% of patients. A low to moderate (10–23%), false negative rate was reported for chest ultrasound-guided needle biopsy. CUS was able to identify mediastinal lymph nodes in as many as 67% of patients with negative chest radiography. Conclusions: Very few studies with important methodological limitations analyze the role of chest ultrasound in the diagnosis of TB. The scarce available data suggests potential targets of future diagnostic or feasibility trials, such as the detection of tuberculosis–related pleural effusion, residual pleural thickening, lymphadenopathy, TB parenchymal patterns, or the use of CUS in biopsy guidance. MDPI 2018-10-12 2018-10 /pmc/articles/PMC6210728/ /pubmed/30322009 http://dx.doi.org/10.3390/ijerph15102235 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Di Gennaro, Francesco
Pisani, Luigi
Veronese, Nicola
Pizzol, Damiano
Lippolis, Valeria
Saracino, Annalisa
Monno, Laura
Huson, Michaëla A.M.
Copetti, Roberto
Putoto, Giovanni
Schultz, Marcus J.
Potential Diagnostic Properties of Chest Ultrasound in Thoracic Tuberculosis—A Systematic Review
title Potential Diagnostic Properties of Chest Ultrasound in Thoracic Tuberculosis—A Systematic Review
title_full Potential Diagnostic Properties of Chest Ultrasound in Thoracic Tuberculosis—A Systematic Review
title_fullStr Potential Diagnostic Properties of Chest Ultrasound in Thoracic Tuberculosis—A Systematic Review
title_full_unstemmed Potential Diagnostic Properties of Chest Ultrasound in Thoracic Tuberculosis—A Systematic Review
title_short Potential Diagnostic Properties of Chest Ultrasound in Thoracic Tuberculosis—A Systematic Review
title_sort potential diagnostic properties of chest ultrasound in thoracic tuberculosis—a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210728/
https://www.ncbi.nlm.nih.gov/pubmed/30322009
http://dx.doi.org/10.3390/ijerph15102235
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