Cargando…

Extraintestinal infections caused by nontyphoidal Salmonella from a tertiary care center in India

BACKGROUND: Infection with Salmonella has become an increasing problem worldwide. Recently, nontyphoid Salmonella (NTS) has become a global concern causing threat to the health of human. It causes gastrointestinal infection which may be self-limiting, but invasive infections may be fatal, requiring...

Descripción completa

Detalles Bibliográficos
Autores principales: Sudhaharan, Sukanya, Kanne, Padmaja, Vemu, Lakshmi, Bhaskara, Aparna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210840/
https://www.ncbi.nlm.nih.gov/pubmed/30498311
http://dx.doi.org/10.4103/JLP.JLP_79_18
_version_ 1783367209575251968
author Sudhaharan, Sukanya
Kanne, Padmaja
Vemu, Lakshmi
Bhaskara, Aparna
author_facet Sudhaharan, Sukanya
Kanne, Padmaja
Vemu, Lakshmi
Bhaskara, Aparna
author_sort Sudhaharan, Sukanya
collection PubMed
description BACKGROUND: Infection with Salmonella has become an increasing problem worldwide. Recently, nontyphoid Salmonella (NTS) has become a global concern causing threat to the health of human. It causes gastrointestinal infection which may be self-limiting, but invasive infections may be fatal, requiring appropriate therapy. This study was done to analyze the spectrum of NTS infections causing extraintestinal infections and its susceptibility pattern from a tertiary care center in India. MATERIALS AND METHODS: The medical records of 27 patients whose cultures were positive for NTS between the years 2013–2016 were included in this retrospective study. The relevant demographic, clinical, and laboratory data were analyzed. RESULTS: Among the 27 patients, predominant patients were in the age group of 20–30 years. The male to female ratio is 1.7:1. Salmonella typhimurium was the predominant NTS isolated among 15/27 (55.5%), followed by Salmonella enteritidis 4/27 (14.8%). 18/27 (66.6%) of NTS were isolated from blood. Nalidixic acid was sensitive in 2/15 of S. typhimurium, 2/4 of S. enteritidis and 1/3 of Salmonella weltevreden, while others are nalidixic acid-resistant implying resistance to quinolones. They were sensitive to other antibiotics reported. CONCLUSION: This study highlights the spectrum of NTS causing extraintestinal infections which is an emerging infection occurring mostly in immunosuppressed individuals. There should be a high degree of clinical suspicion which would help in the early diagnosis and management of patients.
format Online
Article
Text
id pubmed-6210840
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-62108402018-11-29 Extraintestinal infections caused by nontyphoidal Salmonella from a tertiary care center in India Sudhaharan, Sukanya Kanne, Padmaja Vemu, Lakshmi Bhaskara, Aparna J Lab Physicians Original Article BACKGROUND: Infection with Salmonella has become an increasing problem worldwide. Recently, nontyphoid Salmonella (NTS) has become a global concern causing threat to the health of human. It causes gastrointestinal infection which may be self-limiting, but invasive infections may be fatal, requiring appropriate therapy. This study was done to analyze the spectrum of NTS infections causing extraintestinal infections and its susceptibility pattern from a tertiary care center in India. MATERIALS AND METHODS: The medical records of 27 patients whose cultures were positive for NTS between the years 2013–2016 were included in this retrospective study. The relevant demographic, clinical, and laboratory data were analyzed. RESULTS: Among the 27 patients, predominant patients were in the age group of 20–30 years. The male to female ratio is 1.7:1. Salmonella typhimurium was the predominant NTS isolated among 15/27 (55.5%), followed by Salmonella enteritidis 4/27 (14.8%). 18/27 (66.6%) of NTS were isolated from blood. Nalidixic acid was sensitive in 2/15 of S. typhimurium, 2/4 of S. enteritidis and 1/3 of Salmonella weltevreden, while others are nalidixic acid-resistant implying resistance to quinolones. They were sensitive to other antibiotics reported. CONCLUSION: This study highlights the spectrum of NTS causing extraintestinal infections which is an emerging infection occurring mostly in immunosuppressed individuals. There should be a high degree of clinical suspicion which would help in the early diagnosis and management of patients. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6210840/ /pubmed/30498311 http://dx.doi.org/10.4103/JLP.JLP_79_18 Text en Copyright: © 2018 Journal of Laboratory Physicians http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Sudhaharan, Sukanya
Kanne, Padmaja
Vemu, Lakshmi
Bhaskara, Aparna
Extraintestinal infections caused by nontyphoidal Salmonella from a tertiary care center in India
title Extraintestinal infections caused by nontyphoidal Salmonella from a tertiary care center in India
title_full Extraintestinal infections caused by nontyphoidal Salmonella from a tertiary care center in India
title_fullStr Extraintestinal infections caused by nontyphoidal Salmonella from a tertiary care center in India
title_full_unstemmed Extraintestinal infections caused by nontyphoidal Salmonella from a tertiary care center in India
title_short Extraintestinal infections caused by nontyphoidal Salmonella from a tertiary care center in India
title_sort extraintestinal infections caused by nontyphoidal salmonella from a tertiary care center in india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210840/
https://www.ncbi.nlm.nih.gov/pubmed/30498311
http://dx.doi.org/10.4103/JLP.JLP_79_18
work_keys_str_mv AT sudhaharansukanya extraintestinalinfectionscausedbynontyphoidalsalmonellafromatertiarycarecenterinindia
AT kannepadmaja extraintestinalinfectionscausedbynontyphoidalsalmonellafromatertiarycarecenterinindia
AT vemulakshmi extraintestinalinfectionscausedbynontyphoidalsalmonellafromatertiarycarecenterinindia
AT bhaskaraaparna extraintestinalinfectionscausedbynontyphoidalsalmonellafromatertiarycarecenterinindia