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Catheter associated urinary tract infections due to Trichosporon asahii
Urinary tract infections (UTIs) caused by fungi, frequently associated with medical devices, have increased and caused great morbidity and mortality among hospitalized patients. Difficulties on different species identification as well as the lack of standardized sensitivity tests in vitro, contribut...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210852/ https://www.ncbi.nlm.nih.gov/pubmed/30498324 http://dx.doi.org/10.4103/JLP.JLP_71_18 |
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author | Urs, Tejashree Anantharaj Kadiyala, Visakha Deepak, Saundarya Karthik, M Krishna |
author_facet | Urs, Tejashree Anantharaj Kadiyala, Visakha Deepak, Saundarya Karthik, M Krishna |
author_sort | Urs, Tejashree Anantharaj |
collection | PubMed |
description | Urinary tract infections (UTIs) caused by fungi, frequently associated with medical devices, have increased and caused great morbidity and mortality among hospitalized patients. Difficulties on different species identification as well as the lack of standardized sensitivity tests in vitro, contribute to the limited information available on epidemiology, diagnosis, and therapeutics of Trichosporon infections. There are only sporadic reports of UTI caused by Trichosporon asahii reported from India. We report six cases of UTI caused by T. asahii in severely ill patients in a tertiary care setup. Among six positive T. asahii UTI, four were found in female patients with a mean age of 60 years. We observed that all patients were on indwelling urinary catheter, broad-spectrum antibiotics, and with other comorbid conditions. With regard to the antifungal susceptibility testing, all the isolates were resistant to amphotericin B and sensitive to voriconazole. Majority of them were sensitive to Itraconazole, half of them were sensitive to fluconazole. The ubiquity and biofilm formation poses difficulty in establishing pathogenicity and delineating environmental or nosocomial infections. Risk factors such as use of antibiotics, indwelling catheter, and comorbidities such as hypertension, diabetes, anemia, and chronic kidney disease predispose for the development of UTI by T. asahii. Isolation of the same yeast in three consecutive urine samples with significant counts, along with significant number of pus cells establishes T. asahii as an etiological agent of UTI. Furthermore, the clearance of the fungus from the urinary tract with the recovery of the patient following catheter removal and antifungal therapy further confirms T. asahii as the cause of UTI. |
format | Online Article Text |
id | pubmed-6210852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-62108522018-11-29 Catheter associated urinary tract infections due to Trichosporon asahii Urs, Tejashree Anantharaj Kadiyala, Visakha Deepak, Saundarya Karthik, M Krishna J Lab Physicians Case Series Urinary tract infections (UTIs) caused by fungi, frequently associated with medical devices, have increased and caused great morbidity and mortality among hospitalized patients. Difficulties on different species identification as well as the lack of standardized sensitivity tests in vitro, contribute to the limited information available on epidemiology, diagnosis, and therapeutics of Trichosporon infections. There are only sporadic reports of UTI caused by Trichosporon asahii reported from India. We report six cases of UTI caused by T. asahii in severely ill patients in a tertiary care setup. Among six positive T. asahii UTI, four were found in female patients with a mean age of 60 years. We observed that all patients were on indwelling urinary catheter, broad-spectrum antibiotics, and with other comorbid conditions. With regard to the antifungal susceptibility testing, all the isolates were resistant to amphotericin B and sensitive to voriconazole. Majority of them were sensitive to Itraconazole, half of them were sensitive to fluconazole. The ubiquity and biofilm formation poses difficulty in establishing pathogenicity and delineating environmental or nosocomial infections. Risk factors such as use of antibiotics, indwelling catheter, and comorbidities such as hypertension, diabetes, anemia, and chronic kidney disease predispose for the development of UTI by T. asahii. Isolation of the same yeast in three consecutive urine samples with significant counts, along with significant number of pus cells establishes T. asahii as an etiological agent of UTI. Furthermore, the clearance of the fungus from the urinary tract with the recovery of the patient following catheter removal and antifungal therapy further confirms T. asahii as the cause of UTI. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6210852/ /pubmed/30498324 http://dx.doi.org/10.4103/JLP.JLP_71_18 Text en Copyright: © 2018 Journal of Laboratory Physicians http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Series Urs, Tejashree Anantharaj Kadiyala, Visakha Deepak, Saundarya Karthik, M Krishna Catheter associated urinary tract infections due to Trichosporon asahii |
title | Catheter associated urinary tract infections due to Trichosporon asahii |
title_full | Catheter associated urinary tract infections due to Trichosporon asahii |
title_fullStr | Catheter associated urinary tract infections due to Trichosporon asahii |
title_full_unstemmed | Catheter associated urinary tract infections due to Trichosporon asahii |
title_short | Catheter associated urinary tract infections due to Trichosporon asahii |
title_sort | catheter associated urinary tract infections due to trichosporon asahii |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210852/ https://www.ncbi.nlm.nih.gov/pubmed/30498324 http://dx.doi.org/10.4103/JLP.JLP_71_18 |
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