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Use of plasma metabolomics to analyze phenotype-genotype relationships in young hypercholesterolemic females

Hypercholesterolemia is characterized by high plasma LDL cholesterol and often caused by genetic mutations in LDL receptor (LDLR), APOB, or proprotein convertase subtilisin/kexin type 9 (PCSK9). However, a substantial proportion of hypercholesterolemic subjects do not have any mutations in these can...

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Detalles Bibliográficos
Autores principales:	Zhang, Xiang, Rimbert, Antoine, Balder, Willem, Zwinderman, Aeilko Having, Kuivenhoven, Jan Albert, Dallinga-Thie, Geesje Margaretha, Groen, Albert Kornelis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210900/ https://www.ncbi.nlm.nih.gov/pubmed/30266833 http://dx.doi.org/10.1194/jlr.M088930

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