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Factors Associated with Early Mortality in Critically Ill Patients Following the Initiation of Continuous Renal Replacement Therapy

Continuous renal replacement therapy (CRRT) is an important modality to support critically ill patients, and the need for CRRT treatment has been increasing. However, CRRT management is costly, and the associated resources are limited. Thus, it remains challenging to identify patients that are likel...

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Autores principales: Kee, Youn Kyung, Kim, Dahye, Kim, Seung-Jung, Kang, Duk-Hee, Choi, Kyu Bok, Oh, Hyung Jung, Ryu, Dong-Ryeol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210947/
https://www.ncbi.nlm.nih.gov/pubmed/30297660
http://dx.doi.org/10.3390/jcm7100334
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author Kee, Youn Kyung
Kim, Dahye
Kim, Seung-Jung
Kang, Duk-Hee
Choi, Kyu Bok
Oh, Hyung Jung
Ryu, Dong-Ryeol
author_facet Kee, Youn Kyung
Kim, Dahye
Kim, Seung-Jung
Kang, Duk-Hee
Choi, Kyu Bok
Oh, Hyung Jung
Ryu, Dong-Ryeol
author_sort Kee, Youn Kyung
collection PubMed
description Continuous renal replacement therapy (CRRT) is an important modality to support critically ill patients, and the need for CRRT treatment has been increasing. However, CRRT management is costly, and the associated resources are limited. Thus, it remains challenging to identify patients that are likely to have a poor outcome, despite active treatment with CRRT. We sought to elucidate the factors associated with early mortality after CRRT initiation. We analyzed 240 patients who initiated CRRT at an academic medical center between September 2016 and January 2018. We compared baseline characteristics between patients who died within seven days of initiating CRRT (early mortality), and those that survived more than seven days beyond the initiation of CRRT. Of the patients assessed, 130 (54.2%) died within seven days of CRRT initiation. Multivariate logistic regression models revealed that low mean arterial pressure, low arterial pH, and high Sequential Organ Failure Assessment score before CRRT initiation were significantly associated with increased early mortality in patients requiring CRRT. In conclusion, the mortality within seven days following CRRT initiation was very high in this study. We identified several factors that are associated with early mortality in patients undergoing CRRT, which may be useful in predicting early outcomes, despite active treatment with CRRT.
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spelling pubmed-62109472018-11-02 Factors Associated with Early Mortality in Critically Ill Patients Following the Initiation of Continuous Renal Replacement Therapy Kee, Youn Kyung Kim, Dahye Kim, Seung-Jung Kang, Duk-Hee Choi, Kyu Bok Oh, Hyung Jung Ryu, Dong-Ryeol J Clin Med Article Continuous renal replacement therapy (CRRT) is an important modality to support critically ill patients, and the need for CRRT treatment has been increasing. However, CRRT management is costly, and the associated resources are limited. Thus, it remains challenging to identify patients that are likely to have a poor outcome, despite active treatment with CRRT. We sought to elucidate the factors associated with early mortality after CRRT initiation. We analyzed 240 patients who initiated CRRT at an academic medical center between September 2016 and January 2018. We compared baseline characteristics between patients who died within seven days of initiating CRRT (early mortality), and those that survived more than seven days beyond the initiation of CRRT. Of the patients assessed, 130 (54.2%) died within seven days of CRRT initiation. Multivariate logistic regression models revealed that low mean arterial pressure, low arterial pH, and high Sequential Organ Failure Assessment score before CRRT initiation were significantly associated with increased early mortality in patients requiring CRRT. In conclusion, the mortality within seven days following CRRT initiation was very high in this study. We identified several factors that are associated with early mortality in patients undergoing CRRT, which may be useful in predicting early outcomes, despite active treatment with CRRT. MDPI 2018-10-08 /pmc/articles/PMC6210947/ /pubmed/30297660 http://dx.doi.org/10.3390/jcm7100334 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kee, Youn Kyung
Kim, Dahye
Kim, Seung-Jung
Kang, Duk-Hee
Choi, Kyu Bok
Oh, Hyung Jung
Ryu, Dong-Ryeol
Factors Associated with Early Mortality in Critically Ill Patients Following the Initiation of Continuous Renal Replacement Therapy
title Factors Associated with Early Mortality in Critically Ill Patients Following the Initiation of Continuous Renal Replacement Therapy
title_full Factors Associated with Early Mortality in Critically Ill Patients Following the Initiation of Continuous Renal Replacement Therapy
title_fullStr Factors Associated with Early Mortality in Critically Ill Patients Following the Initiation of Continuous Renal Replacement Therapy
title_full_unstemmed Factors Associated with Early Mortality in Critically Ill Patients Following the Initiation of Continuous Renal Replacement Therapy
title_short Factors Associated with Early Mortality in Critically Ill Patients Following the Initiation of Continuous Renal Replacement Therapy
title_sort factors associated with early mortality in critically ill patients following the initiation of continuous renal replacement therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210947/
https://www.ncbi.nlm.nih.gov/pubmed/30297660
http://dx.doi.org/10.3390/jcm7100334
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