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Depression Negatively Impacts Survival of Patients with Metastatic Prostate Cancer

The prevalence of depression in patients with cancer is high, especially for patients with advanced cancer. In this study, we evaluated the prevalence of depression in prostate cancer patients in Taiwan and the association between depression and mortality in prostate cancer. This study included 1101...

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Autores principales: Lin, Po-Hung, Liu, Jui-Ming, Hsu, Ren-Jun, Chuang, Heng-Chang, Chang, Su-Wei, Pang, See-Tong, Chang, Ying-Hsu, Chuang, Cheng-Keng, Lin, Shun-Ku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210974/
https://www.ncbi.nlm.nih.gov/pubmed/30274322
http://dx.doi.org/10.3390/ijerph15102148
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author Lin, Po-Hung
Liu, Jui-Ming
Hsu, Ren-Jun
Chuang, Heng-Chang
Chang, Su-Wei
Pang, See-Tong
Chang, Ying-Hsu
Chuang, Cheng-Keng
Lin, Shun-Ku
author_facet Lin, Po-Hung
Liu, Jui-Ming
Hsu, Ren-Jun
Chuang, Heng-Chang
Chang, Su-Wei
Pang, See-Tong
Chang, Ying-Hsu
Chuang, Cheng-Keng
Lin, Shun-Ku
author_sort Lin, Po-Hung
collection PubMed
description The prevalence of depression in patients with cancer is high, especially for patients with advanced cancer. In this study, we evaluated the prevalence of depression in prostate cancer patients in Taiwan and the association between depression and mortality in prostate cancer. This study included 1101 newly diagnosed patients with prostate cancer. We tracked the medical information of these patients from diagnosis until the end of 2012. Patients were divided into two groups according to presence or absence of depression diagnosis, and were further divided into three stages by initial treatments: localized or locally advanced, metastatic, and castration-resistant prostate cancer. Of 1101 participants, 267 (24.3%) had depression. By the end of the follow-up period (M = 8.30 ± 3.12 years), 77 (28.8%) patients in the depression group and 194 (23.3%) in the non-depressed group died. Depression was associated with higher mortality risk, (aHR 1.37; 95% CI [ 1.04–1.80]; p value 0.01). Patients in the metastatic prostate cancer group with depression had a significantly higher mortality risk compared to the non-depressed group, (aHR, 1.49; 95% CI [1.05–2.11]; p value 0.02). The impact of depression on mortality risk was not significant in either the localized or locally advanced or the castration-resistant prostate cancer groups. Our study showed that depression is related to an increased mortality risk for patients with prostate cancer, especially for metastatic prostate cancer. These results indicate that urologists should pay attention to the mood and psychiatric disorders of patients with prostate cancer.
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spelling pubmed-62109742018-11-02 Depression Negatively Impacts Survival of Patients with Metastatic Prostate Cancer Lin, Po-Hung Liu, Jui-Ming Hsu, Ren-Jun Chuang, Heng-Chang Chang, Su-Wei Pang, See-Tong Chang, Ying-Hsu Chuang, Cheng-Keng Lin, Shun-Ku Int J Environ Res Public Health Article The prevalence of depression in patients with cancer is high, especially for patients with advanced cancer. In this study, we evaluated the prevalence of depression in prostate cancer patients in Taiwan and the association between depression and mortality in prostate cancer. This study included 1101 newly diagnosed patients with prostate cancer. We tracked the medical information of these patients from diagnosis until the end of 2012. Patients were divided into two groups according to presence or absence of depression diagnosis, and were further divided into three stages by initial treatments: localized or locally advanced, metastatic, and castration-resistant prostate cancer. Of 1101 participants, 267 (24.3%) had depression. By the end of the follow-up period (M = 8.30 ± 3.12 years), 77 (28.8%) patients in the depression group and 194 (23.3%) in the non-depressed group died. Depression was associated with higher mortality risk, (aHR 1.37; 95% CI [ 1.04–1.80]; p value 0.01). Patients in the metastatic prostate cancer group with depression had a significantly higher mortality risk compared to the non-depressed group, (aHR, 1.49; 95% CI [1.05–2.11]; p value 0.02). The impact of depression on mortality risk was not significant in either the localized or locally advanced or the castration-resistant prostate cancer groups. Our study showed that depression is related to an increased mortality risk for patients with prostate cancer, especially for metastatic prostate cancer. These results indicate that urologists should pay attention to the mood and psychiatric disorders of patients with prostate cancer. MDPI 2018-09-29 2018-10 /pmc/articles/PMC6210974/ /pubmed/30274322 http://dx.doi.org/10.3390/ijerph15102148 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Po-Hung
Liu, Jui-Ming
Hsu, Ren-Jun
Chuang, Heng-Chang
Chang, Su-Wei
Pang, See-Tong
Chang, Ying-Hsu
Chuang, Cheng-Keng
Lin, Shun-Ku
Depression Negatively Impacts Survival of Patients with Metastatic Prostate Cancer
title Depression Negatively Impacts Survival of Patients with Metastatic Prostate Cancer
title_full Depression Negatively Impacts Survival of Patients with Metastatic Prostate Cancer
title_fullStr Depression Negatively Impacts Survival of Patients with Metastatic Prostate Cancer
title_full_unstemmed Depression Negatively Impacts Survival of Patients with Metastatic Prostate Cancer
title_short Depression Negatively Impacts Survival of Patients with Metastatic Prostate Cancer
title_sort depression negatively impacts survival of patients with metastatic prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210974/
https://www.ncbi.nlm.nih.gov/pubmed/30274322
http://dx.doi.org/10.3390/ijerph15102148
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