Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine Treatment

To find new anti-cancer drug therapies, we wanted to exploit homeostatic vulnerabilities within Tuberous Sclerosis Complex 2 (TSC2)-deficient cells with mechanistic target of rapamycin complex 1 (mTORC1) hyperactivity. We show that nelfinavir and mefloquine synergize to selectively evoke a cytotoxic...

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Detalles Bibliográficos
Autores principales: McCann, Henry D., Johnson, Charlotte E., Errington, Rachel J., Davies, D. Mark, Dunlop, Elaine A., Tee, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210998/
https://www.ncbi.nlm.nih.gov/pubmed/30308940
http://dx.doi.org/10.3390/cancers10100375

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