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How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research

Tumor hypoxia is related with tumor aggressiveness, chemo- and radiotherapy resistance, and thus a poor clinical outcome. Therefore, over the past decades, every effort has been made to develop strategies to battle the negative prognostic influence of tumor hypoxia. For appropriate patient selection...

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Autores principales: De Bruycker, Sven, Vangestel, Christel, Staelens, Steven, Van den Wyngaert, Tim, Stroobants, Sigrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211155/
https://www.ncbi.nlm.nih.gov/pubmed/30420794
http://dx.doi.org/10.1155/2018/4608186
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author De Bruycker, Sven
Vangestel, Christel
Staelens, Steven
Van den Wyngaert, Tim
Stroobants, Sigrid
author_facet De Bruycker, Sven
Vangestel, Christel
Staelens, Steven
Van den Wyngaert, Tim
Stroobants, Sigrid
author_sort De Bruycker, Sven
collection PubMed
description Tumor hypoxia is related with tumor aggressiveness, chemo- and radiotherapy resistance, and thus a poor clinical outcome. Therefore, over the past decades, every effort has been made to develop strategies to battle the negative prognostic influence of tumor hypoxia. For appropriate patient selection and follow-up, noninvasive imaging biomarkers such as positron emission tomography (PET) radiolabeled ligands are unprecedentedly needed. Importantly, before being able to implement these new therapies and potential biomarkers into the clinical setting, preclinical in vivo validation in adequate animal models is indispensable. In this review, we provide an overview of the different attempts that have been made to create differential hypoxic in vivo cancer models with a particular focus on their applicability in PET imaging studies.
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spelling pubmed-62111552018-11-12 How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research De Bruycker, Sven Vangestel, Christel Staelens, Steven Van den Wyngaert, Tim Stroobants, Sigrid Contrast Media Mol Imaging Review Article Tumor hypoxia is related with tumor aggressiveness, chemo- and radiotherapy resistance, and thus a poor clinical outcome. Therefore, over the past decades, every effort has been made to develop strategies to battle the negative prognostic influence of tumor hypoxia. For appropriate patient selection and follow-up, noninvasive imaging biomarkers such as positron emission tomography (PET) radiolabeled ligands are unprecedentedly needed. Importantly, before being able to implement these new therapies and potential biomarkers into the clinical setting, preclinical in vivo validation in adequate animal models is indispensable. In this review, we provide an overview of the different attempts that have been made to create differential hypoxic in vivo cancer models with a particular focus on their applicability in PET imaging studies. Hindawi 2018-10-18 /pmc/articles/PMC6211155/ /pubmed/30420794 http://dx.doi.org/10.1155/2018/4608186 Text en Copyright © 2018 Sven De Bruycker et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
De Bruycker, Sven
Vangestel, Christel
Staelens, Steven
Van den Wyngaert, Tim
Stroobants, Sigrid
How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research
title How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research
title_full How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research
title_fullStr How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research
title_full_unstemmed How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research
title_short How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research
title_sort how to modulate tumor hypoxia for preclinical in vivo imaging research
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211155/
https://www.ncbi.nlm.nih.gov/pubmed/30420794
http://dx.doi.org/10.1155/2018/4608186
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