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Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course
Accelerated DNA methylation age is linked to all-cause mortality and environmental factors, but studies of associations with socioeconomic position are limited. Researchers generally use small selected samples, and it is unclear how findings obtained with 2 commonly used methods for calculating meth...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211240/ https://www.ncbi.nlm.nih.gov/pubmed/30060108 http://dx.doi.org/10.1093/aje/kwy155 |
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author | Hughes, Amanda Smart, Melissa Gorrie-Stone, Tyler Hannon, Eilis Mill, Jonathan Bao, Yanchun Burrage, Joe Schalkwyk, Leo Kumari, Meena |
author_facet | Hughes, Amanda Smart, Melissa Gorrie-Stone, Tyler Hannon, Eilis Mill, Jonathan Bao, Yanchun Burrage, Joe Schalkwyk, Leo Kumari, Meena |
author_sort | Hughes, Amanda |
collection | PubMed |
description | Accelerated DNA methylation age is linked to all-cause mortality and environmental factors, but studies of associations with socioeconomic position are limited. Researchers generally use small selected samples, and it is unclear how findings obtained with 2 commonly used methods for calculating methylation age (the Horvath method and the Hannum method) translate to general population samples including younger and older adults. Among 1,099 United Kingdom adults aged 28–98 years in 2011–2012, we assessed the relationship of Horvath and Hannum DNA methylation age acceleration with a range of social position measures: current income and employment, education, income and unemployment across a 12-year period, and childhood social class. Accounting for confounders, participants who had been less advantaged in childhood were epigenetically “older” as adults: In comparison with participants who had professional/managerial parents, Hannum age was 1.07 years higher (95% confidence interval: 0.20, 1.94) for participants with parents in semiskilled/unskilled occupations and 1.85 years higher (95% confidence interval: 0.67, 3.02) for those without a working parent at age 14 years. No other robust associations were seen. Results accord with research implicating early life circumstances as critical for DNA methylation age in adulthood. Since methylation age acceleration as measured by the Horvath and Hannum estimators appears strongly linked to chronological age, researchers examining associations with the social environment must take steps to avoid age-related confounding. |
format | Online Article Text |
id | pubmed-6211240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-62112402018-11-05 Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course Hughes, Amanda Smart, Melissa Gorrie-Stone, Tyler Hannon, Eilis Mill, Jonathan Bao, Yanchun Burrage, Joe Schalkwyk, Leo Kumari, Meena Am J Epidemiol Original Contributions Accelerated DNA methylation age is linked to all-cause mortality and environmental factors, but studies of associations with socioeconomic position are limited. Researchers generally use small selected samples, and it is unclear how findings obtained with 2 commonly used methods for calculating methylation age (the Horvath method and the Hannum method) translate to general population samples including younger and older adults. Among 1,099 United Kingdom adults aged 28–98 years in 2011–2012, we assessed the relationship of Horvath and Hannum DNA methylation age acceleration with a range of social position measures: current income and employment, education, income and unemployment across a 12-year period, and childhood social class. Accounting for confounders, participants who had been less advantaged in childhood were epigenetically “older” as adults: In comparison with participants who had professional/managerial parents, Hannum age was 1.07 years higher (95% confidence interval: 0.20, 1.94) for participants with parents in semiskilled/unskilled occupations and 1.85 years higher (95% confidence interval: 0.67, 3.02) for those without a working parent at age 14 years. No other robust associations were seen. Results accord with research implicating early life circumstances as critical for DNA methylation age in adulthood. Since methylation age acceleration as measured by the Horvath and Hannum estimators appears strongly linked to chronological age, researchers examining associations with the social environment must take steps to avoid age-related confounding. Oxford University Press 2018-11 2018-07-27 /pmc/articles/PMC6211240/ /pubmed/30060108 http://dx.doi.org/10.1093/aje/kwy155 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Contributions Hughes, Amanda Smart, Melissa Gorrie-Stone, Tyler Hannon, Eilis Mill, Jonathan Bao, Yanchun Burrage, Joe Schalkwyk, Leo Kumari, Meena Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course |
title | Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course |
title_full | Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course |
title_fullStr | Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course |
title_full_unstemmed | Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course |
title_short | Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course |
title_sort | socioeconomic position and dna methylation age acceleration across the life course |
topic | Original Contributions |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211240/ https://www.ncbi.nlm.nih.gov/pubmed/30060108 http://dx.doi.org/10.1093/aje/kwy155 |
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