Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [(18)F] PET tracer

A series of novel derivatives exhibiting high affinity and selectivity towards the COX-2 enzyme in the (aza) indazole series was developed. A short synthetic route involving a bromination/arylation sequence under microwave irradiation and direct C–H activation were established in the indazole and az...

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Detalles Bibliográficos
Autores principales: Elie, Jonathan, Vercouillie, Johnny, Arlicot, Nicolas, Lemaire, Lucas, Bidault, Rudy, Bodard, Sylvie, Hosselet, Christel, Deloye, Jean-Bernard, Chalon, Sylvie, Emond, Patrick, Guilloteau, Denis, Buron, Frédéric, Routier, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211253/
https://www.ncbi.nlm.nih.gov/pubmed/30362376
http://dx.doi.org/10.1080/14756366.2018.1501043

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