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Design, synthesis, in vitro anticancer evaluation, kinase inhibitory effects, and pharmacokinetic profile of new 1,3,4-triarylpyrazole derivatives possessing terminal sulfonamide moiety

The present work describes the design and synthesis of a novel series of 1,3-diaryl-4-sulfonamidoarylpyrazole derivatives 1a–q and 2a–q and their in vitro biological activities. The target compounds were evaluated for antiproliferative activity against NCI-60 cell line panel. Compounds 1c, 1g, 1k–m,...

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Detalles Bibliográficos
Autores principales:	Abdel-Maksoud, Mohammed S., El-Gamal, Mohammed I., Gamal El-Din, Mahmoud M., Oh, Chang Hyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211260/ https://www.ncbi.nlm.nih.gov/pubmed/30362383 http://dx.doi.org/10.1080/14756366.2018.1530225

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