Visualizing the dynamics of histone variants in the S-phase nucleus

Histone variants constitute a fundamental feature of the epigenome. However, their dynamics during normal and challenged DNA replication and their distribution in the three-dimensional space of the nucleus remain poorly characterized. A recent study employed stochastic optical reconstruction microsc...

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Autores principales: Maxouri, Stella, Taraviras, Stavros, Lygerou, Zoi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211500/
https://www.ncbi.nlm.nih.gov/pubmed/30382897
http://dx.doi.org/10.1186/s13059-018-1556-4
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author Maxouri, Stella
Taraviras, Stavros
Lygerou, Zoi
author_facet Maxouri, Stella
Taraviras, Stavros
Lygerou, Zoi
author_sort Maxouri, Stella
collection PubMed
description Histone variants constitute a fundamental feature of the epigenome. However, their dynamics during normal and challenged DNA replication and their distribution in the three-dimensional space of the nucleus remain poorly characterized. A recent study employed stochastic optical reconstruction microscopy (STORM) to obtain a high-resolution view of the spatial distribution of H3 histone variants in the nucleus and related this to the timing of DNA replication.
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spelling pubmed-62115002018-11-08 Visualizing the dynamics of histone variants in the S-phase nucleus Maxouri, Stella Taraviras, Stavros Lygerou, Zoi Genome Biol Research Highlight Histone variants constitute a fundamental feature of the epigenome. However, their dynamics during normal and challenged DNA replication and their distribution in the three-dimensional space of the nucleus remain poorly characterized. A recent study employed stochastic optical reconstruction microscopy (STORM) to obtain a high-resolution view of the spatial distribution of H3 histone variants in the nucleus and related this to the timing of DNA replication. BioMed Central 2018-10-31 /pmc/articles/PMC6211500/ /pubmed/30382897 http://dx.doi.org/10.1186/s13059-018-1556-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Maxouri, Stella
Taraviras, Stavros
Lygerou, Zoi
Visualizing the dynamics of histone variants in the S-phase nucleus
title Visualizing the dynamics of histone variants in the S-phase nucleus
title_full Visualizing the dynamics of histone variants in the S-phase nucleus
title_fullStr Visualizing the dynamics of histone variants in the S-phase nucleus
title_full_unstemmed Visualizing the dynamics of histone variants in the S-phase nucleus
title_short Visualizing the dynamics of histone variants in the S-phase nucleus
title_sort visualizing the dynamics of histone variants in the s-phase nucleus
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211500/
https://www.ncbi.nlm.nih.gov/pubmed/30382897
http://dx.doi.org/10.1186/s13059-018-1556-4
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