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Aberrant PRDM9 expression impacts the pan-cancer genomic landscape

The binding of PRDM9 to chromatin is a key step in the induction of DNA double-strand breaks associated with meiotic recombination hotspots; it is normally expressed solely in germ cells. We interrogated 1879 cancer samples in 39 different cancer types and found that PRDM9 is unexpectedly expressed...

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Detalles Bibliográficos
Autores principales:	Houle, Armande Ang, Gibling, Heather, Lamaze, Fabien C., Edgington, Hilary A., Soave, David, Fave, Marie-Julie, Agbessi, Mawusse, Bruat, Vanessa, Stein, Lincoln D., Awadalla, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211651/ https://www.ncbi.nlm.nih.gov/pubmed/30341163 http://dx.doi.org/10.1101/gr.231696.117

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