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Effect of white-coat hypertension on arterial stiffness: A meta-analysis

BACKGROUND: White-coat hypertension (WCH) is a debatable risk factor of cardio-cerebrovascular diseases and the current study results on the association between WCH and arterial stiffness are inconsistent. The aim was to investigate the effect of WCH on arterial stiffness using meta-analysis. METHOD...

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Detalles Bibliográficos
Autores principales: Cai, Peng, Peng, Yan, Wang, Yan, Wang, Xukai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212289/
https://www.ncbi.nlm.nih.gov/pubmed/30335012
http://dx.doi.org/10.1097/MD.0000000000012888
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author Cai, Peng
Peng, Yan
Wang, Yan
Wang, Xukai
author_facet Cai, Peng
Peng, Yan
Wang, Yan
Wang, Xukai
author_sort Cai, Peng
collection PubMed
description BACKGROUND: White-coat hypertension (WCH) is a debatable risk factor of cardio-cerebrovascular diseases and the current study results on the association between WCH and arterial stiffness are inconsistent. The aim was to investigate the effect of WCH on arterial stiffness using meta-analysis. METHODS: Based on prespecified search strategies and inclusion criteria, Medline, Embase, Web Of Science, Cochrane Library, and BioSciences Information Service Preview databases were reviewed. A total of 20 studies involving 1538 WCH patients and 3582 normotensives (NT) were included. Literatures were screened for data extraction and quality assessment. Overall analysis and subgroup analysis were conducted in RevMan version 5.3 and Stata version 14.0 software. RESULTS: Overall analysis showed that carotid-femoral pulse wave velocity (cf-PWV) was significantly higher in WCH group than in the NT group (P < .00001, 95% CI: 0.79–3.26). Subgroup analysis showed that in adults, cf-PWV was significantly higher in the WCH patients than in the NT subjects (P<.001, 95% CI: 0.46–0.87), while in juveniles, cf-PWV was comparable between the WCH group and the NT group (P = .25, 95% CI: −0.39 to 0.61). CONCLUSION: This meta-analysis showed that WCH may increase arterial stiffness in adult population.
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spelling pubmed-62122892018-11-27 Effect of white-coat hypertension on arterial stiffness: A meta-analysis Cai, Peng Peng, Yan Wang, Yan Wang, Xukai Medicine (Baltimore) Research Article BACKGROUND: White-coat hypertension (WCH) is a debatable risk factor of cardio-cerebrovascular diseases and the current study results on the association between WCH and arterial stiffness are inconsistent. The aim was to investigate the effect of WCH on arterial stiffness using meta-analysis. METHODS: Based on prespecified search strategies and inclusion criteria, Medline, Embase, Web Of Science, Cochrane Library, and BioSciences Information Service Preview databases were reviewed. A total of 20 studies involving 1538 WCH patients and 3582 normotensives (NT) were included. Literatures were screened for data extraction and quality assessment. Overall analysis and subgroup analysis were conducted in RevMan version 5.3 and Stata version 14.0 software. RESULTS: Overall analysis showed that carotid-femoral pulse wave velocity (cf-PWV) was significantly higher in WCH group than in the NT group (P < .00001, 95% CI: 0.79–3.26). Subgroup analysis showed that in adults, cf-PWV was significantly higher in the WCH patients than in the NT subjects (P<.001, 95% CI: 0.46–0.87), while in juveniles, cf-PWV was comparable between the WCH group and the NT group (P = .25, 95% CI: −0.39 to 0.61). CONCLUSION: This meta-analysis showed that WCH may increase arterial stiffness in adult population. Wolters Kluwer Health 2018-10-19 /pmc/articles/PMC6212289/ /pubmed/30335012 http://dx.doi.org/10.1097/MD.0000000000012888 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Article
Cai, Peng
Peng, Yan
Wang, Yan
Wang, Xukai
Effect of white-coat hypertension on arterial stiffness: A meta-analysis
title Effect of white-coat hypertension on arterial stiffness: A meta-analysis
title_full Effect of white-coat hypertension on arterial stiffness: A meta-analysis
title_fullStr Effect of white-coat hypertension on arterial stiffness: A meta-analysis
title_full_unstemmed Effect of white-coat hypertension on arterial stiffness: A meta-analysis
title_short Effect of white-coat hypertension on arterial stiffness: A meta-analysis
title_sort effect of white-coat hypertension on arterial stiffness: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212289/
https://www.ncbi.nlm.nih.gov/pubmed/30335012
http://dx.doi.org/10.1097/MD.0000000000012888
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