Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure

Heart failure (HF) is characterized by abnormal mitochondrial calcium (Ca(2+)) handling, energy failure and impaired mitophagy resulting in contractile dysfunction and myocyte death. We have previously shown that the 18-kDa mitochondrial translocator protein of the outer mitochondrial membrane (TSPO...

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Detalles Bibliográficos
Autores principales: Thai, Phung N., Daugherty, Daniel J., Frederich, Bert J., Lu, Xiyuan, Deng, Wenbin, Bers, Donald M., Dedkova, Elena N., Schaefer, Saul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212397/
https://www.ncbi.nlm.nih.gov/pubmed/30385779
http://dx.doi.org/10.1038/s41598-018-34451-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212397/
https://www.ncbi.nlm.nih.gov/pubmed/30385779
http://dx.doi.org/10.1038/s41598-018-34451-2

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