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The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives

A series of chemsensors (1–4) containing fluorobenzene group based on coumarin derivatives have been developed for the selective and sensitive detection of H(2)S. The advantages of the synthesized fluorescent probe (compound 1) were the low detection limit (4 × 10(−6) mol·L(−1)), good selectivity an...

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Autores principales: Chen, Yanmei, Shang, Xuefang, Li, Congshu, Xue, Zhenzhen, Chen, Hongli, Wu, Hongwei, Wang, Tianyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212500/
https://www.ncbi.nlm.nih.gov/pubmed/30385799
http://dx.doi.org/10.1038/s41598-018-34331-9
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author Chen, Yanmei
Shang, Xuefang
Li, Congshu
Xue, Zhenzhen
Chen, Hongli
Wu, Hongwei
Wang, Tianyun
author_facet Chen, Yanmei
Shang, Xuefang
Li, Congshu
Xue, Zhenzhen
Chen, Hongli
Wu, Hongwei
Wang, Tianyun
author_sort Chen, Yanmei
collection PubMed
description A series of chemsensors (1–4) containing fluorobenzene group based on coumarin derivatives have been developed for the selective and sensitive detection of H(2)S. The advantages of the synthesized fluorescent probe (compound 1) were the low detection limit (4 × 10(−6) mol·L(−1)), good selectivity and high sensitivity which had been demonstrated through UV-vis, fluorescent titration experiments. Besides cytotoxicity test of compounds (1 and 2) was studied and the results indicated that compounds (1 and 2) showed almost no cytotoxicityat at a concentration of 150 μg·mL(−1). The interacted mechanism was the thiolysis reaction of dinitrophenyl ether which had been confirmed by fluorescence and HRMS titration experiment. In addition, probe 1 can also detect HS(−) selectively by naked eye in pure DMSO solvent.
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spelling pubmed-62125002018-11-06 The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives Chen, Yanmei Shang, Xuefang Li, Congshu Xue, Zhenzhen Chen, Hongli Wu, Hongwei Wang, Tianyun Sci Rep Article A series of chemsensors (1–4) containing fluorobenzene group based on coumarin derivatives have been developed for the selective and sensitive detection of H(2)S. The advantages of the synthesized fluorescent probe (compound 1) were the low detection limit (4 × 10(−6) mol·L(−1)), good selectivity and high sensitivity which had been demonstrated through UV-vis, fluorescent titration experiments. Besides cytotoxicity test of compounds (1 and 2) was studied and the results indicated that compounds (1 and 2) showed almost no cytotoxicityat at a concentration of 150 μg·mL(−1). The interacted mechanism was the thiolysis reaction of dinitrophenyl ether which had been confirmed by fluorescence and HRMS titration experiment. In addition, probe 1 can also detect HS(−) selectively by naked eye in pure DMSO solvent. Nature Publishing Group UK 2018-11-01 /pmc/articles/PMC6212500/ /pubmed/30385799 http://dx.doi.org/10.1038/s41598-018-34331-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen, Yanmei
Shang, Xuefang
Li, Congshu
Xue, Zhenzhen
Chen, Hongli
Wu, Hongwei
Wang, Tianyun
The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives
title The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives
title_full The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives
title_fullStr The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives
title_full_unstemmed The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives
title_short The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives
title_sort synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212500/
https://www.ncbi.nlm.nih.gov/pubmed/30385799
http://dx.doi.org/10.1038/s41598-018-34331-9
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