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Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis

Immunoproteasome (IP) inhibition holds potential as a novel treatment option for various immune-mediated pathologies. The IP inhibitor ONX 0914 reduced T cell cytokine secretion and Th17 polarization and showed pre-clinical efficacy in a range of autoimmune disorders, transplant-allograft rejection,...

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Detalles Bibliográficos
Autores principales:	Schmidt, Christian, Berger, Thilo, Groettrup, Marcus, Basler, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212513/ https://www.ncbi.nlm.nih.gov/pubmed/30416500 http://dx.doi.org/10.3389/fimmu.2018.02386

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