Allosteric Site Inhibitor Disrupting Auto-Processing of Malarial Cysteine Proteases

Falcipains are major haemoglobinases of Plasmodium falciparum required for parasite growth and development. They consist of pro- and mature domains that interact via ‘hot-spot’ interactions and maintain the structural integrity of enzyme in zymogen state. Upon sensing the acidic environment, these i...

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Detalles Bibliográficos
Autores principales: Pant, A., Kumar, R., Wani, N. A., Verma, S., Sharma, R., Pande, V., Saxena, A. K., Dixit, R., Rai, R., Pandey, K. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212536/
https://www.ncbi.nlm.nih.gov/pubmed/30385827
http://dx.doi.org/10.1038/s41598-018-34564-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212536/
https://www.ncbi.nlm.nih.gov/pubmed/30385827
http://dx.doi.org/10.1038/s41598-018-34564-8

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