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Allosteric Site Inhibitor Disrupting Auto-Processing of Malarial Cysteine Proteases
Falcipains are major haemoglobinases of Plasmodium falciparum required for parasite growth and development. They consist of pro- and mature domains that interact via ‘hot-spot’ interactions and maintain the structural integrity of enzyme in zymogen state. Upon sensing the acidic environment, these i...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212536/ https://www.ncbi.nlm.nih.gov/pubmed/30385827 http://dx.doi.org/10.1038/s41598-018-34564-8 |