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Design of metalloproteins and novel protein folds using variational autoencoders

The design of novel proteins has many applications but remains an attritional process with success in isolated cases. Meanwhile, deep learning technologies have exploded in popularity in recent years and are increasingly applicable to biology due to the rise in available data. We attempt to link pro...

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Detalles Bibliográficos
Autores principales: Greener, Joe G., Moffat, Lewis, Jones, David T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212568/
https://www.ncbi.nlm.nih.gov/pubmed/30385875
http://dx.doi.org/10.1038/s41598-018-34533-1

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