Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain

The YEATS domain has been identified as a reader of histone acylation and more recently emerged as a promising anti-cancer therapeutic target. Here, we detail the structural mechanisms for π-π-π stacking involving the YEATS domains of yeast Taf14 and human AF9 and acylated histone H3 peptides and ex...

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Detalles Bibliográficos
Autores principales: Klein, Brianna J., Vann, Kendra R., Andrews, Forest H., Wang, Wesley W., Zhang, Jibo, Zhang, Yi, Beloglazkina, Anastasia A., Mi, Wenyi, Li, Yuanyuan, Li, Haitao, Shi, Xiaobing, Kutateladze, Andrei G., Strahl, Brian D., Liu, Wenshe R., Kutateladze, Tatiana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212594/
https://www.ncbi.nlm.nih.gov/pubmed/30385749
http://dx.doi.org/10.1038/s41467-018-07072-6

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