Cargando…

Evaluation of Chemokines in the Gingival Crevicular Fluid of Children with Down Syndrome

AIM: The goal of the study was to detect the presence of macrophage inflammatory protein (MIP)-1α and MIP-1β and to estimate their levels in gingival crevicular fluid (GCF) of children with Down syndrome. MATERIALS AND METHODS: MIP-1α and MIP-1β levels were estimated in GCF samples of 20 healthy and...

Descripción completa

Detalles Bibliográficos
Autores principales: Reddy, Veerakishore K, Kommineni, Naveen K, Padakandla, Prathyusha, Togaru, Harshini, Indupalli, John P, Nanga, Swapna P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212665/
https://www.ncbi.nlm.nih.gov/pubmed/30397372
http://dx.doi.org/10.5005/jp-journals-10005-1528
_version_ 1783367589232115712
author Reddy, Veerakishore K
Kommineni, Naveen K
Padakandla, Prathyusha
Togaru, Harshini
Indupalli, John P
Nanga, Swapna P
author_facet Reddy, Veerakishore K
Kommineni, Naveen K
Padakandla, Prathyusha
Togaru, Harshini
Indupalli, John P
Nanga, Swapna P
author_sort Reddy, Veerakishore K
collection PubMed
description AIM: The goal of the study was to detect the presence of macrophage inflammatory protein (MIP)-1α and MIP-1β and to estimate their levels in gingival crevicular fluid (GCF) of children with Down syndrome. MATERIALS AND METHODS: MIP-1α and MIP-1β levels were estimated in GCF samples of 20 healthy and 20 Down syndrome individuals. Gingival status was assessed by measuring the gingival index (GI), plaque index (PI), clinical attachment level (CAL), and probing pocket depth (PPD). The GCF samples were obtained from the subjects and MIP-1α and MIP-1β levels were quantified by enzyme-linked immunosorbent assay (ELISA). RESULTS: The mean MIP-1α concentrations in healthy and Down syndrome individuals were 209 and 1411 pg/μL respectively, and MIP-1α levels were 342 and 1404 pg/μL respectively. The levels of MIP-1α and MIP-1β in the GCF of subjects with Down syndrome were significantly higher than in the healthy individual, and statistically significant differences were present among the two groups. CONCLUSION: The GCF showed dynamic changes according to the severity of periodontal disease, and the levels of MIP-1α and MIP-1β had a strong relationship with clinical parameters. The MIP-1α and MIP-1β can therefore be considered as novel biomarkers in the biological mechanism underlying the patho-genesis of periodontal disease. How to cite this article: Reddy VK, Kommineni NK, Padakandla P, Togaru H, Indupalli JP, Nanga SP. Evaluation of Chemokines in the Gingival Crevicular Fluid of Children with Down Syndrome. Int J Clin Pediatr Dent 2018;11(4):288-293.
format Online
Article
Text
id pubmed-6212665
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Jaypee Brothers Medical Publishers
record_format MEDLINE/PubMed
spelling pubmed-62126652018-11-05 Evaluation of Chemokines in the Gingival Crevicular Fluid of Children with Down Syndrome Reddy, Veerakishore K Kommineni, Naveen K Padakandla, Prathyusha Togaru, Harshini Indupalli, John P Nanga, Swapna P Int J Clin Pediatr Dent Original Article AIM: The goal of the study was to detect the presence of macrophage inflammatory protein (MIP)-1α and MIP-1β and to estimate their levels in gingival crevicular fluid (GCF) of children with Down syndrome. MATERIALS AND METHODS: MIP-1α and MIP-1β levels were estimated in GCF samples of 20 healthy and 20 Down syndrome individuals. Gingival status was assessed by measuring the gingival index (GI), plaque index (PI), clinical attachment level (CAL), and probing pocket depth (PPD). The GCF samples were obtained from the subjects and MIP-1α and MIP-1β levels were quantified by enzyme-linked immunosorbent assay (ELISA). RESULTS: The mean MIP-1α concentrations in healthy and Down syndrome individuals were 209 and 1411 pg/μL respectively, and MIP-1α levels were 342 and 1404 pg/μL respectively. The levels of MIP-1α and MIP-1β in the GCF of subjects with Down syndrome were significantly higher than in the healthy individual, and statistically significant differences were present among the two groups. CONCLUSION: The GCF showed dynamic changes according to the severity of periodontal disease, and the levels of MIP-1α and MIP-1β had a strong relationship with clinical parameters. The MIP-1α and MIP-1β can therefore be considered as novel biomarkers in the biological mechanism underlying the patho-genesis of periodontal disease. How to cite this article: Reddy VK, Kommineni NK, Padakandla P, Togaru H, Indupalli JP, Nanga SP. Evaluation of Chemokines in the Gingival Crevicular Fluid of Children with Down Syndrome. Int J Clin Pediatr Dent 2018;11(4):288-293. Jaypee Brothers Medical Publishers 2018 2018-08-01 /pmc/articles/PMC6212665/ /pubmed/30397372 http://dx.doi.org/10.5005/jp-journals-10005-1528 Text en Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Original Article
Reddy, Veerakishore K
Kommineni, Naveen K
Padakandla, Prathyusha
Togaru, Harshini
Indupalli, John P
Nanga, Swapna P
Evaluation of Chemokines in the Gingival Crevicular Fluid of Children with Down Syndrome
title Evaluation of Chemokines in the Gingival Crevicular Fluid of Children with Down Syndrome
title_full Evaluation of Chemokines in the Gingival Crevicular Fluid of Children with Down Syndrome
title_fullStr Evaluation of Chemokines in the Gingival Crevicular Fluid of Children with Down Syndrome
title_full_unstemmed Evaluation of Chemokines in the Gingival Crevicular Fluid of Children with Down Syndrome
title_short Evaluation of Chemokines in the Gingival Crevicular Fluid of Children with Down Syndrome
title_sort evaluation of chemokines in the gingival crevicular fluid of children with down syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212665/
https://www.ncbi.nlm.nih.gov/pubmed/30397372
http://dx.doi.org/10.5005/jp-journals-10005-1528
work_keys_str_mv AT reddyveerakishorek evaluationofchemokinesinthegingivalcrevicularfluidofchildrenwithdownsyndrome
AT kommineninaveenk evaluationofchemokinesinthegingivalcrevicularfluidofchildrenwithdownsyndrome
AT padakandlaprathyusha evaluationofchemokinesinthegingivalcrevicularfluidofchildrenwithdownsyndrome
AT togaruharshini evaluationofchemokinesinthegingivalcrevicularfluidofchildrenwithdownsyndrome
AT indupallijohnp evaluationofchemokinesinthegingivalcrevicularfluidofchildrenwithdownsyndrome
AT nangaswapnap evaluationofchemokinesinthegingivalcrevicularfluidofchildrenwithdownsyndrome