Precision oncology: separating the wheat from the chaff

Precision oncology based on next-generation sequencing (NGS) test is growing in daily clinical practice. However, the real impact of this strategy in patients’ outcome on a large scale remains uncertain. In this review, we summarise existing literature on this topic, limitations for broad NGS implem...

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Detalles Bibliográficos
Autores principales: Remon, Jordi, Dienstmann, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212683/
https://www.ncbi.nlm.nih.gov/pubmed/30425845
http://dx.doi.org/10.1136/esmoopen-2018-000446
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author Remon, Jordi
Dienstmann, Rodrigo
author_facet Remon, Jordi
Dienstmann, Rodrigo
author_sort Remon, Jordi
collection PubMed
description Precision oncology based on next-generation sequencing (NGS) test is growing in daily clinical practice. However, the real impact of this strategy in patients’ outcome on a large scale remains uncertain. In this review, we summarise existing literature on this topic, limitations for broad NGS implementation, bottlenecks in genomic variant interpretation and the role of molecular tumour boards.
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spelling pubmed-62126832018-11-13 Precision oncology: separating the wheat from the chaff Remon, Jordi Dienstmann, Rodrigo ESMO Open Review Precision oncology based on next-generation sequencing (NGS) test is growing in daily clinical practice. However, the real impact of this strategy in patients’ outcome on a large scale remains uncertain. In this review, we summarise existing literature on this topic, limitations for broad NGS implementation, bottlenecks in genomic variant interpretation and the role of molecular tumour boards. BMJ Publishing Group 2018-10-30 /pmc/articles/PMC6212683/ /pubmed/30425845 http://dx.doi.org/10.1136/esmoopen-2018-000446 Text en © Author (s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ on behalf of the European Society for Medical Oncology. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, any changes made are indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Review
Remon, Jordi
Dienstmann, Rodrigo
Precision oncology: separating the wheat from the chaff
title Precision oncology: separating the wheat from the chaff
title_full Precision oncology: separating the wheat from the chaff
title_fullStr Precision oncology: separating the wheat from the chaff
title_full_unstemmed Precision oncology: separating the wheat from the chaff
title_short Precision oncology: separating the wheat from the chaff
title_sort precision oncology: separating the wheat from the chaff
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212683/
https://www.ncbi.nlm.nih.gov/pubmed/30425845
http://dx.doi.org/10.1136/esmoopen-2018-000446
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