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Role of nucleotide identity in effective CRISPR target escape mutations

Prokaryotes use primed CRISPR adaptation to update their memory bank of spacers against invading genetic elements that have escaped CRISPR interference through mutations in their protospacer target site. We previously observed a trend that nucleotide-dependent mismatches between crRNA and the protos...

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Detalles Bibliográficos
Autores principales:	Künne, Tim, Zhu, Yifan, da Silva, Fausia, Konstantinides, Nico, McKenzie, Rebecca E, Jackson, Ryan N, Brouns, Stan JJ
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212716/ https://www.ncbi.nlm.nih.gov/pubmed/30107450 http://dx.doi.org/10.1093/nar/gky687

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